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首页> 外文期刊>European journal of clinical nutrition >Essential fatty acids in breast milk of atopic mothers: comparison with non-atopic mothers, and effect of borage oil supplementation.
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Essential fatty acids in breast milk of atopic mothers: comparison with non-atopic mothers, and effect of borage oil supplementation.

机译：特应性母亲的母乳中的必需脂肪酸：与非特应性母亲的比较，以及琉璃苣油补充剂的作用。

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OBJECTIVE: To evaluate whether levels of n-6 long chain polyunsaturated fatty acids (LCPs) in human breast milk are related to the mother's atopic constitution, and whether a decreased level can be restored by gamma-linolenic acid supplementation. DESIGN: Cross-sectional study and dietary supplementation trial. SUBJECTS: 20 atopic mothers and 20 non-atopic mothers (controls), all lactating. Setting: General population. INTERVENTIONS: The atopic mothers were randomly assigned to low (n=10) or high (n=10) dosage oral supplementation with oral borage oil for one week (230 or 460 mg gamma-linolenic acid (18:3n-6) per day). Main outcome measures: Essential fatty acid composition of the breast milk total fat fraction, determined by gas liquid chromatography. RESULTS: Arachidonic acid (20:4n-6) was lower in breast milk of atopic mothers compared with non-atopic mothers (0.39 wt% vs 0.46 wt%, difference -0.07% wt% (95% confidence limits -0.13, -0.01 wt%; P<0. 05). The ratio between linoleic acid and the sum of n-6 derivatives did not differ between these groups, indicating no difference in delta-6-desaturase (D6D) activity. Supplementation of the atopic mothers significantly increased the levels of gamma-linolenic acid and dihomo-gamma-linolenic acid in breast milk in a dose-related way, but the level of arachidonic acid was not increased. CONCLUSION: We found a decreased level of arachidonic acid in breast milk in atopic compared to non-atopic mothers, but no indication that the rate-limiting enzymatic step (D6D) is involved. Supplementation increased the precursor pool but did not restore the level of arachidonic acid. We conclude that atopy is related to a metabolic disturbance beyond the D6D enzymatic step. A low level of arachidonic acid in breast milk may be a risk factor for the development of atopy in the infant, especially when the possible underlying metabolic disturbance of EFA metabolism is inherited by the child. SPONSORSHIP: F Hoffman-La Roche (Basel, Switzerland) and Friesland Dairy Foods (Leeuwarden, The Netherlands).
机译：目的：评估母乳中n-6长链多不饱和脂肪酸（LCPs）的水平是否与母亲的特应性体质有关，以及是否可以通过补充γ-亚麻酸来恢复下降的水平。设计：横断面研究和膳食补充试验。受试者：20名特应性母亲和20名非特应性母亲（对照），均在哺乳​​期。地点：一般人口。干预措施：特应性母亲被随机分配为低剂量（n = 10）或高剂量（n = 10）口服琉璃苣油，每天口服一次（230或460 mgγ-亚麻酸（18：3n-6），每天） ）。主要结果指标：通过气相色谱法测定的母乳中总脂肪酸成分的必需脂肪酸组成。结果：特应性母亲的母乳中花生四烯酸（20：4n-6）低于非特应性母亲（0.39 wt％vs 0.46 wt％，差异为-0.07％wt％（95％置信限-0.13，-0.01） wt％; P <0。05）。这些组之间亚油酸与n-6衍生物总和之间的比例没有差异，表明delta-6-去饱和酶（D6D）活性无差异。结论：我们发现特应性母乳中花生四烯酸的含量降低了，但剂量相关的方式增加了母乳中γ-亚麻酸和二高-γ-亚麻酸的含量，但并没有增加花生四烯酸的含量。与非特应性母亲相比，但没有迹象表明限速酶促步骤（D6D）参与;补充增加了前体库，但没有恢复花生四烯酸的水平。 D6D酶促步骤。花生四烯酸含量低母乳中的d可能是婴儿患特应性疾病的危险因素，尤其是当儿童遗传了EFA代谢的潜在潜在代谢紊乱时。发起人：F Hoffman-La Roche（瑞士巴塞尔）和Friesland Dairy Foods（荷兰吕伐登）。

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