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首页> 外文期刊>European journal of clinical nutrition >Reliability of fatty acid composition in human serum phospholipids.
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Reliability of fatty acid composition in human serum phospholipids.

机译：人血清磷脂中脂肪酸组成的可靠性。

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OBJECTIVE: We examined the reliability of the fatty acid composition of serum phospholipids in the New York University Women's Health Study, a prospective study of sex hormones, diet and breast cancer. DESIGN: Non-fasting serum samples collected at three yearly visits, in 46 healthy women, and stored at -80 degrees C for 7-12 y, were included in the study. Serum phospholipid fatty acid composition was measured by capillary gas chromatography. RESULTS: For the 20 individual fatty acids measured, the reliability coefficients were less than 0.50 for four, between 0.50 and 0.70 for nine, and greater than 0.70 for seven. Among the major fatty acids, arachidonic and alpha-linolenic acids had high reliability coefficients (0.71 and 0. 72, respectively), palmitic, oleic, linoleic, eicosapentaenoic and docosahexaenoic acids had intermediate coefficients (0.57, 0.69, 0. 62, 0.64 and 0.66, respectively), whereas stearic acid had the lowest coefficient (0.15). The reliability coefficients for total monounsaturated fats, omega-6 and omega-3 fatty acids were moderately high (0.66, 0.53 and 0.66, respectively), whereas the coefficients for total saturated fats and total polyunsaturated fats were low (0.31 and 0.43, respectively). CONCLUSIONS: These results indicate that the fatty acid composition of serum phospholipids can be a useful tool in epidemiologic studies, although for most fatty acids a single determination is associated with some error in measurement that should be taken into account at the design and analysis stages. Storage for up to 12 y at -80 degrees C preserved polyunsaturated fatty acids from oxidation very well.
机译：目的：我们在纽约大学妇女健康研究中对血清磷脂脂肪酸成分的可靠性进行了研究，该研究是对性激素，饮食和乳腺癌的前瞻性研究。设计：该研究包括在46名健康女性中每3年进行一次随访的非禁食血清样本，并在-80摄氏度下保存7-12年。通过毛细管气相色谱法测定血清磷脂脂肪酸组成。结果：对于所测量的20种单独脂肪酸，四项的可靠性系数小于0.50，九项的可靠性系数在0.50和0.70之间，七项的可靠性系数大于0.70。在主要脂肪酸中，花生四烯酸和α-亚麻酸具有较高的可靠性系数（分别为0.71和0. 72），棕榈酸，油酸，亚油酸，二十碳五烯酸和二十二碳六烯酸具有中等系数（0.57、0.69、0。62、0.64和分别为0.66）和硬脂酸系数最低（0.15）。总单不饱和脂肪，omega-6和omega-3脂肪酸的可靠性系数适中较高（分别为0.66、0.53和0.66），而总饱和脂肪和总多不饱和脂肪的可靠性系数较低（分别为0.31和0.43） 。结论：这些结果表明，血清磷脂的脂肪酸组成可以作为流行病学研究的有用工具，尽管对于大多数脂肪酸而言，单一测定与测量误差有关，在设计和分析阶段应予以考虑。在-80摄氏度下最多可保存12年，可防止多不饱和脂肪酸氧化。

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