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首页> 外文期刊>European journal of clinical nutrition >Appetite dysfunction in obese males: evidence for role of hyperinsulinaemia in passive overconsumption with a high fat diet.
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Appetite dysfunction in obese males: evidence for role of hyperinsulinaemia in passive overconsumption with a high fat diet.

机译：肥胖男性的食欲障碍：高胰岛素饮食在高脂饮食被动过度消费中的作用证据。

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OBJECTIVE: To test the hypothesis that caloric and fat intake in a pre-load meal have no subsequent effects upon blood glucose and insulin concentrations, perceived hunger, subsequent food intake and appetite control in lean and obese men. DESIGN: Lean and obese men reported to the laboratory in the morning in a fasted state where they were subject to an eating test based on the pre-load-test meal paradigm, using a double-blind protocol. The breakfast pre-load was either a reduced caloric low-fat (LF) meal or an overfeeding high-fat (HF) meal. LF was 20% of each individual's average daily energy requirement (ADER) and comprised 60% carbohydrate, 27% protein, and 13% fat, whilst HF was adjusted to yield 55% of the ADER, and comprised 45% carbohydrate, 22% protein and 43% fat. The pre-loads on both trials were administered as one single mean, and were given in a random order. After 5(1/2) h, an ad libitum test-lunch was given to determine how much energy was consumed. Between the two meals, blood samples were collected and subjective hunger ratings were assessed hourly. These variables were measured at 30-min intervals for 75 min after the ad libitum meal. STUDY PARTICIPANTS: Twelve healthy men, six of whom were lean (BMI 22. 50+/-1.08 kg.m2) and six of whom were obese (BMI 39.05+/-11.63 kg. m2) were recruited. RESULTS: When given 55% of their ADER in a HF pre-load meal, the obese group consumed more energy (5426+/-1126 kJ; F1,20=11.45, P<0.01), than the lean group did (3473+/-1114 kJ), accounting for 45% of the ADER in that meal setting. However, no differences between lean and obese intake were noted at the test meal following a LF pre-load. The lean group exhibited a significant inverse correlation (r=0.628, P<0.05) between serum insulin concentration before eating the test meal and the amount of energy consumed at the test meal, while such a relationship was absent in the obese group. CONCLUSION: The obese males were unable to compensate for the caloric overloading when fed a HF (55% ADER) pre-load at a subsequent test meal, whereas a calorically reduced pre-load (20% ADER) produced similar intakes to the lean control group. The inverse relationship noted in the lean group between insulin levels before the test meal and the energy intake at that test meal suggests that insulin may play a role in the regulation of appetite - satiety mechanism in lean males. The absence of such a relationship in the obese may suggest the site for possible appetite dysfunction contributing to obesity. These results further suggest that when obese individuals consume a high-fat meal they are prone to passive overconsumption, whereas lean study participants appear to be more resistant to such a phenomenon.
机译：目的：为了检验以下假设，即瘦人和肥胖男性的餐前热量和脂肪摄入对血糖和胰岛素浓度，感知的饥饿感，随后的食物摄入和食欲控制没有后续影响。设计：瘦弱和肥胖的男性在早上禁食时向实验室报告，他们根据双负荷试验方案，根据负荷前测试膳食范例接受饮食测试。早餐的预负荷是低热量低脂（LF）餐或高营养高脂（HF）餐。 LF是每个人平均每日能量需求（ADER）的20％，包含60％的碳水化合物，27％的蛋白质和13％的脂肪，而HF进行调整以产生55％的ADER，并且包含45％的碳水化合物，22％的蛋白质和43％的脂肪。两项试验的预负荷均以一个均值进行管理，并以随机顺序给出。 5（1/2）小时后，随意进行午餐测试，以确定消耗了多少能量。在两顿饭之间，收集血液样本，每小时评估一次主观饥饿感。随意进餐后以30分钟为间隔测量这些变量，持续75分钟。研究对象：招募了十二名健康男性，其中六人瘦（BMI 22. 50 +/- 1.08 kg.m2），其中六人肥胖（BMI 39.05 +/- 11.63 kg.m2）。结果：在HF预负荷餐中给予其55％的ADER时，肥胖组的能量消耗（5426 +/- 1126 kJ; F1,20 = 11.45，P <0.01），而瘦肉组的能量消耗（3473+ / -1114 kJ），占该餐位设置中ADER的45％。但是，LF预负荷后，在测试餐中没有发现瘦摄入量和肥胖摄入量之间的差异。瘦肉组在进食测试餐前的血清胰岛素浓度与测试餐所消耗的能量之间显示出显着的负相关（r = 0.628，P <0.05），而在肥胖组中则没有这种关系。结论：肥胖男性无法在随后的测试餐中喂入HF（55％ADER）预负荷时补偿热量超负荷，而热量减少的预负荷（20％ADER）产生的饮食与瘦肉对照组相似组。在瘦肉组中，在测试膳食之前的胰岛素水平与该测试膳食的能量摄入之间存在反比关系，这表明胰岛素可能在瘦男性的食欲-饱腹感调节中发挥作用。肥胖中没有这种关系可能表明该部位可能是导致肥胖的食欲不振的原因。这些结果进一步表明，肥胖的人食用高脂餐时，他们倾向于被动地过度消费，而精瘦的研究参与者似乎更能抵抗这种现象。

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