...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of clinical nutrition >Intravenous acetate elicits a greater free fatty acid rebound in normal than hyperinsulinaemic humans
【24h】

Intravenous acetate elicits a greater free fatty acid rebound in normal than hyperinsulinaemic humans

机译：与高胰岛素血症人相比，静脉注射乙酸盐在正常情况下引起更大的游离脂肪酸反弹

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background/objectives:Colonic fermentation of dietary fiber may improve insulin sensitivity by the metabolic effects of short chain fatty acids (SCFA) in reducing free fatty acids (FFA). The main objectives of this study were to compare peripheral uptake of acetate (AC) in participants with normal (40 pmol/l, NI) and high (40 pmol/l, HI) plasma insulin, and the ability of AC to reduce FFA in both the groups.Subjects/methods:Overnight fasted NI (n9) and HI (n9) participants were given an intravenous (IV) infusion of 140 mmol/l sodium acetate at three different rates over 90 min. The total amount of AC infused was 51.85 mmols.Results:AC clearance in NI participants was not significantly different than that in HI participants (2.110.23 vs 2.090.24 ml/min). FFA fell in both the groups, but rebounded to a greater extent in NI than HI participants (time × group interaction, P0.001). Significant correlations between insulin resistance (IR) indices (homeostasis model assessment of insulin resistance (HOMA-IR), Matsuda and insulinogenic index) vs FFA rebound during IV AC infusion were also observed.Conclusions:These findings suggest that AC uptake is similar in both the groups. Participants with lower plasma insulin and lower IR indices had a greater FFA rebound. These results support the hypothesis that increasing AC concentrations in the systemic circulation may reduce lipolysis and plasma FFA concentrations and thus improve insulin sensitivity. More in-depth studies are needed to look at the effects of SCFA on FFA metabolism in insulin-resistant participants.
机译：背景/目标：膳食纤维的结肠发酵可通过短链脂肪酸（SCFA）在减少游离脂肪酸（FFA）方面的代谢作用来提高胰岛素敏感性。这项研究的主要目的是比较正常（40 pmol / l，NI）和高（40 pmol / l，HI）血浆胰岛素的参与者外周乙酸盐（AC）的摄取，以及AC降低糖尿病患者FFA的能力。受试者/方法：隔夜禁食的NI（n9）和HI（n9）参与者在90分钟内以三种不同的速率静脉内输注140 mmol / l乙酸钠。结果表明：NI参与者的交流清除率与HI参与者的清除率无显着差异（2.110.23 vs. 2.090.24 ml / min）。两组的FFA均下降，但NI的反弹大于HI参与者（时间×组交互作用，P0.001）。静脉AC输注期间，胰岛素抵抗（IR）指数（胰岛素抵抗的稳态模型评估（HOMA-IR），松田和胰岛素生成指数）与FFA反弹之间也存在显着相关性。组。血浆胰岛素水平较低且IR指数较低的参与者的FFA反弹较大。这些结果支持这样的假设，即全身循环中AC浓度的增加可能会减少脂解作用和血浆FFA浓度，从而改善胰岛素敏感性。需要更深入的研究来观察SCFA对胰岛素抵抗参与者中FFA代谢的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号