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首页> 外文期刊>European journal of clinical nutrition >MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults
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MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults

机译：MRI测量的骨盆骨髓脂肪组织与DXA测量的年轻人和老年人骨矿物质成反比

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Background/Objectives:Recent research has shown an inverse relationship between bone marrow adipose tissue (BMAT) and bone mineral density (BMD). There is a lack of evidence at the macro-imaging level to establish whether increased BMAT is a cause or effect of bone loss. This cross-sectional study compared the BMAT and BMD relationship between a younger adult group at or approaching peak bone mass (PBM; age 18.0-39.9 years) and an older group with potential bone loss (PoBL; age 40.0-88.0 years). Subjects/Methods:Pelvic BMAT was evaluated in 560 healthy men and women with T1-weighted whole-body magnetic resonance imaging. BMD was measured using whole-body dual-energy X-ray absorptiometry.Results:An inverse correlation was observed between pelvic BMAT and pelvic, total and spine BMD in the younger PBM group (r0.419 to 0.461, P0.001) and in the older PoBL group (r0.405 to 0.500, P0.001). After adjusting for age, sex, ethnicity, menopausal status, total body fat, skeletal muscle, subcutaneous and visceral adipose tissue, neither subject group (younger PBM vs older PoBL) nor its interaction with pelvic BMAT significantly contributed to the regression models with BMD as dependent variable and pelvic BMAT as independent variable (P0.434-0.928).Conclusions:Our findings indicate that an inverse relationship between pelvic BMAT and BMD is present both in younger subjects who have not yet experienced bone loss and also in older subjects. These results provide support at the macro-imaging level for the hypothesis that low BMD may be a result of preferential differentiation of mesenchymal stem cells from osteoblasts to adipocytes.
机译：背景/目的：最近的研究表明，骨髓脂肪组织（BMAT）与骨矿物质密度（BMD）之间存在反比关系。在宏观成像水平上缺乏证据来确定增加的BMAT是骨丢失的原因还是结果。这项横断面研究比较了处于或接近峰值骨质量的较年轻成年人组（PBM;年龄18.0-39.9岁）与具有潜在骨丢失的较年长组（PoBL;年龄40.0-88.0岁）之间的BMAT和BMD关系。对象/方法：采用T1加权全身磁共振成像技术对560名健康的男性和女性进行骨盆BMAT评估。结果：在年轻的PBM组（r0.419至0.461，P0.001）和年轻的PBM组中，骨盆BMAT与骨盆，总骨密度和脊柱BMD呈负相关。 PoBL组年龄较大（r0.405至0.500，P0.001）。在调整了年龄，性别，种族，绝经状态，总脂肪，骨骼肌，皮下和内脏脂肪组织后，受试者组（年轻的PBM相对于较老的PoBL）及其与骨盆BMAT的相互作用均未显着影响以BMD作为回归模型结论：我们的研究结果表明，骨质BMAT与BMD之间存在反比关系，既未发生骨质流失的年轻受试者，也存在较老的受试者。这些结果在宏观成像水平上为以下假设提供了支持：低BMD可能是间充质干细胞从成骨细胞到脂肪细胞优先分化的结果。

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