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首页> 外文期刊>European journal of clinical nutrition >Evidence for augmented oxidative stress in the subjects with type 1 diabetes and their siblings: A possible preventive role for antioxidants
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Evidence for augmented oxidative stress in the subjects with type 1 diabetes and their siblings: A possible preventive role for antioxidants

机译：1型糖尿病及其兄弟姐妹中氧化应激增加的证据：抗氧化剂的可能预防作用

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Background/Objectives:Oxidative stress (OS) is thought to be involved in both development of type 1 diabetes (T1D) and its further complications. In this study, certain biomarkers of OS were compared among the subjects with T1D, their non-diabetic siblings and unrelated healthy controls.Subjects/Methods: Known cases of T1D from both sexes aged 5-25 years were enrolled in a case-control study (n 1 60). There were two control groups; non-diabetic siblings (n 2 60) and unrelated apparently healthy subjects (n 3 60). Anthropometric, dietary and laboratory assessments were done.Results:There was no significant difference in dietary data among the groups. Total antioxidant capacity was significantly lower in T1D than both related and unrelated controls (1.60.05, 1.70.05 and 1.80.06 mmol BSA equivalent/l, respectively, P0.044). Both T1D subjects and their siblings showed lower glutathione peroxidase (GSH-px) levels (median (interquartile range): 22.2 (28.6), 29.9 (23) and 41.8 (73.6) U/ml, respectively, P0.006). On the contrary, superoxide dismutase concentrations were significantly higher in T1D group and the siblings than unrelated healthy controls (243 (45.3), 157.8 (176.9) and 27.9 (8.7) U/l, respectively, P0.001). Serum concentrations of GSH correlated with energy intake in the siblings (r0.521, P0.001) and unrelated controls (r0.268, P0.042) but not in T1D group. The associations remained significant after controlling for blood glucose (r0.437, P0.001 and r0.420, P0.011, respectively) in both the groups.Conclusion:Augmented OS in the siblings may indicate an increased requirement for antioxidants in genetically diabetes-prone subjects.
机译：背景/目的：氧化应激（OS）被认为与1型糖尿病（T1D）的发展及其进一步的并发症有关。在这项研究中，比较了患有T1D的受试者，其非糖尿病兄弟姐妹和无关健康对照者中OS的某些生物标志物。受试者/方法：病例对照研究纳入了5-25岁男女的T1D已知病例。 （n 1 60）。有两个对照组。非糖尿病兄弟姐妹（n 2 60）和无关的明显健康的受试者（n 3 60）。结果：各组之间的饮食数据没有显着差异。 T1D中的总抗氧化剂能力显着低于相关和不相关的对照（分别为1.60.05、1.70.05和1.80.06 mmol BSA当量/升，P0.044）。 T1D受试者及其兄弟姐妹均显示出较低的谷胱甘肽过氧化物酶（GSH-px）水平（中位（四分位间距）：分别为22.2（28.6），29.9（23）和41.8（73.6）U / ml，P0.006）。相反，T1D组和同胞中的超氧化物歧化酶浓度显着高于无关健康对照者（分别为243（45.3），157.8（176.9）和27.9（8.7）U / l，P0.001）。血清GSH的浓度与兄弟姐妹（r0.521，P0.001）和无关对照组（r0.268，P0.042）的能量摄入相关，而在T1D组中则与能量摄入无关。两组血糖控制后的相关性仍然很显着（分别为r0.437，P0.001和r0.420，P0.011）。结论：兄弟姐妹的OS升高可能表明遗传性糖尿病患者对抗氧化剂的需求增加容易发生的主题。

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