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首页> 外文期刊>European journal of clinical nutrition >Feto-maternal vitamin D status and infant whole-body bone mineral content in the first weeks of life
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Feto-maternal vitamin D status and infant whole-body bone mineral content in the first weeks of life

机译：生命最初几周的胎儿母体维生素D状况和婴儿全身骨矿物质含量

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Background/Objectives:Compromised vitamin D status is common in pregnancy and may have adverse impacts on fetal development. The purpose of this study was to investigate the association of infant whole-body bone mineral content (WBBMC) at 8-21 days of age with feto-maternal vitamin D status in a multiethnic population in Oakland, California.Subjects/Methods:This was a cross-sectional study of 120 women and their newborn infants. Maternal and cord blood were collected at delivery. WBBMC was measured by dual-energy X-ray absorptiometry in term-born infants 8-21days post birth.Results:No significant association was observed between unadjusted or size-adjusted WBBMC and feto-maternal vitamin D status analyzed continuously or categorically. In multivariate modeling, unadjusted WBBMC was predicted by bone area (P0.0001), weight-for-age (P0.0001) and weight-for-length (P0.0005) Z-scores, but not by feto-maternal vitamin D status. Anthropometric predictors but not vitamin D remained significant in the multivariate model after adjustment of WBBMC for weight, bone area (bone mineral density) or logarithmically derived exponents of the denominators.ConclusionS: Results of the present study do not support an association between feto-maternal vitamin D status and early infant WBBMC, raw or adjusted for inter-individual differences in size, in a multiethnic population in Northern California.
机译：背景/目的：维生素D状况低下在孕妇中很常见，可能会对胎儿发育产生不利影响。这项研究的目的是调查在加利福尼亚州奥克兰多种族人群中8-21天的婴儿全身骨骼矿物质含量（WBBMC）与胎儿母体维生素D状况之间的关系。一项针对120名妇女及其新生儿的横断面研究。分娩时收集母体和脐带血。通过双能X射线吸收法对出生后8-21天的足月儿进行WBBMC测量。在多变量建模中，未调整的WBBMC可以通过骨骼面积（P0.0001），年龄重量（P0.0001）和体重重量（P0.0005）Z分数来预测，但不能通过胎儿母体维生素D来预测状态。在调整体重，骨面积（骨矿物质密度）或对数的对数指数后，对WBBBC进行调整后，人体模型预测指标（而非维生素D）在多变量模型中仍然很重要。在北加利福尼亚的多种族人群中，维生素D的状况和婴儿WBBMC的原始状态或根据个体之间的大小差异进行了调整。

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