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首页> 外文期刊>European journal of cancer care >Quality of life related to oral mucositis of patients undergoing haematopoietic stem cell transplantation and receiving specialised oral care with low-level laser therapy: a prospective observational study
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Quality of life related to oral mucositis of patients undergoing haematopoietic stem cell transplantation and receiving specialised oral care with low-level laser therapy: a prospective observational study

机译：接受造血干细胞移植并接受低水平激光治疗的特殊口腔护理的患者口腔黏膜炎的生活质量：一项前瞻性观察研究

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摘要

Oral mucositis is a painful condition that occurs in 80% of patients who undergo haematopoietic stem cell transplantation (HSCT). Our objective was to determine the impact of mucositis on quality of life (QoL) of patients subjected to HSCT treated with low-level laser therapy (LLLT). Patients were evaluated: (1) on the first day of treatment; (2) 5 days after autologous or 8 days after allogeneic transplantation; (3) once bone marrow had integrated; and (4) 30 days after discharge. Clinical evaluation was performed using the World Health Organization criteria; oral health QoL was measured using the Oral Health Impact Profile (OHIP-14); and mucositis symptoms with the Patient-Reported Oral Mucositis Symptom (PROMS) scale. The higher the score, the lower the patient's QoL. The OHIP-14 responses showed that at D + 5/D + 8, all domains had the highest scores, while at times 1 and 4, the scores were lower. In the PROMS scale, all domains scored worst at time 2, and the differences between the scores at the four times were statistically significant. The study has shown that QoL improves over time in patients undergoing LLLT therapy for mucositis prevention.
机译：口腔粘膜炎是一种痛苦的疾病，发生在80％的造血干细胞移植（HSCT）患者中。我们的目标是确定粘膜炎对接受低水平激光治疗（LLLT）的HSCT患者的生活质量（QoL）的影响。对患者进行了评估：（1）在治疗的第一天; （2）自体移植后5天或异体移植后8天; （3）骨髓整合后; （4）出院后30天。使用世界卫生组织的标准进行临床评估;口腔健康QoL使用口腔健康影响资料（OHIP-14）进行测量;病人报告的口腔粘膜炎症状（PROMS）量表的评分和粘膜炎症状。分数越高，患者的生活质量越低。 OHIP-14响应显示，在D + 5 / D + 8时，所有域的得分最高，而在时间1和4时，得分较低。在PROMS量表中，所有域在时间2得分最差，并且四次得分之间的差异具有统计学意义。该研究表明，接受LLLT治疗预防粘膜炎的患者的QoL随着时间的推移而改善。

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