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首页> 外文期刊>European journal of clinical pharmacology >Esomeprazole 40 mg provides more effective intragastric acid control than lansoprazole 30 mg, omeprazole 20 mg, pantoprazole 40 mg and rabeprazole 20 mg in patients with gastro-oesophageal reflux symptoms.
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Esomeprazole 40 mg provides more effective intragastric acid control than lansoprazole 30 mg, omeprazole 20 mg, pantoprazole 40 mg and rabeprazole 20 mg in patients with gastro-oesophageal reflux symptoms.

机译：对于胃食管反流症状的患者，埃索美拉唑40毫克比兰索拉唑30毫克，奥美拉唑20毫克，pan托拉唑40毫克和雷贝拉唑20毫克能更有效地控制胃酸。

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OBJECTIVE: To compare the effect of esomeprazole 40 mg with lansoprazole 30 mg, omeprazole 20 mg, pantoprazole 40 mg and rabeprazole 20 mg on intragastric pH during single and repeated dosing in four separate studies in patients with symptoms of gastro-oesophageal reflux disorder (GERD). METHODS: In four randomised crossover studies, patients with symptoms of GERD received once-daily treatment with esomeprazole 40 mg or lansoprazole 30 mg (study A), omeprazole 20 mg (study B), pantoprazole 40 mg (study C) and rabeprazole 20 mg (study D) for 5 days. Continuous 24-h intragastric pH recording was performed on days 1 (except study B) and 5. Percentage of time over 24 h with intragastric pH greater than 4, 24-h median pH and the proportion of patients with pH greater than 4 for greater than or equal to 12 h and 16 h during the 24-h recording periods were investigated. RESULTS: In all four studies, esomeprazole 40 mg OD maintained intragastric pH greater than 4 for a significantly higher mean percentage of the 24-h period compared with all other proton pump inhibitors (PPIs) on days 1 (esomeprazole 40.6% versus lansoprazole 33.4%, P=0.0182; esomeprazole 50.3% versus pantoprazole 29.1%, P<0.001; esomeprazole 41.0% versus rabeprazole 29.4%, P=0.002) and 5 (esomeprazole 57.7% versus lansoprazole 44.5%, P<0.0001; esomeprazole 69.8% versus omeprazole 43.7%, P<0.0001; esomeprazole 67.0% versus pantoprazole 44.8%, P<0.001; esomeprazole 59.4% versus rabeprazole 44.5%, P<0.0001). Higher 24-h median pH and a higher proportion of patients with intragastric pH greater than 4 for greater than or equal to 12 h and 16 h were reported with esomeprazole 40 mg OD than with all the other PPIs in each study. CONCLUSION: Esomeprazole 40 mg provides greater acid control in more patients and maintains intragastric pH greater than 4 for a longer period than lansoprazole 30 mg, omeprazole 20 mg, pantoprazole 40 mg and rabeprazole 20 mg in patients with symptoms of GERD.
机译：目的：在四项单独的研究中，在有胃食管反流症状（GERD）的患者中，单次和重复给药期间，比较40 mg埃索美拉唑，lansoprazole 30 mg，奥美拉唑20 mg，pantoprazole 40 mg和雷贝拉唑20 mg对胃内pH值的影响）。方法：在四项随机交叉研究中，患有GERD症状的患者每天接受一次埃索美拉唑40毫克或兰索拉唑30毫克（研究A），奥美拉唑20毫克（研究B），pan托拉唑40毫克（研究C）和雷贝拉唑20毫克治疗（研究D），为期5天。在第1天（研究B除外）和第5天连续进行24小时胃内pH记录。胃内pH大于4、24小时中值pH和pH大于4的患者所占比例超过24研究了在24小时录制期间内等于或等于12小时和16小时。结果：在所有四项研究中，与所有其他质子泵抑制剂（PPI）在第1天相比，埃索美拉唑40 mg OD维持24小时内的胃内pH值均明显高于4（埃索美拉唑40.6％，兰索拉唑33.4％ ，P = 0.0182;埃索美拉唑50.3％，比pan托拉唑29.1％，P <0.001;埃索美拉唑41.0％，比雷贝拉唑29.4％，P = 0.002）和5（埃索美拉唑57.7％，比兰索拉唑44.5％，P <0.0001;埃索美拉唑69.8％，奥美拉唑43.7 ％，P ＜0.0001;埃索美拉唑67.0％对pan托拉唑44.8％，P ＜0.001;埃索美拉唑59.4％对雷贝拉唑44.5％，P ＜0.0001）。与每项研究中的所有其他PPI相比，依索美拉唑40 mg OD的患者报告的24小时中位pH值更高，且胃内pH大于4的患者在12小时和16小时内的比例更高。结论：对于患有GERD症状的患者，与兰索拉唑30 mg，奥美拉唑20 mg，pan托拉唑40 mg和雷贝拉唑20 mg相比，埃索美拉唑40 mg在更多患者中提供更好的酸控制，并在更长的时间内保持胃内pH大于4。

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