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首页> 外文期刊>European journal of clinical nutrition >The effect of vitamin D and frailty on mortality among non- institutionalized US older adults
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The effect of vitamin D and frailty on mortality among non- institutionalized US older adults

机译：维生素D和体弱对未住院的美国老年人死亡率的影响

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Background/Objectives:Although both frailty and low vitamin D have been separately associated with an increased risk for adverse health, their joined effects on mortality have not been reported. The current study examined prospectively the effects of frailty and vitamin D status on mortality in US older adults.Subjects/Methods:Participants aged 60 years in The Third National Health and Nutrition Examination Survey with 12 years of mortality follow-up were included in the analysis (n4731). Frailty was defined as meeting three or more criteria and pre-frailty as meeting one or two of the five frailty criteria (low body mass index (BMI), slow walking, weakness, exhaustion and low physical activity). Vitamin D status was assessed by serum 25-hydroxyvitamin D (25(OH)D) and categorized into quartiles. Analyses were adjusted for gender, race, age, smoking, education, latitude and other comorbid conditions.Results:Serum 25(OH)D concentrations were lowest in participants with frailty, intermediate in participants with pre-frailty and highest in participants without frailty. The odds of frailty in the lowest quartile of serum 25(OH)D was 1.94 times the odds in the highest quartile (95% confidence interval (CI): 1.09-3.44). Mortality was positively associated with frailty, with the risk among participants who were frail and had low serum 25(OH)D being significantly higher than those who were not frail and who had high concentrations of serum 25(OH)D (hazards ratio 2.98; 95% CI: 2.01-4.42).Conclusion:Our results suggest that low serum 25(OH)D is associated with frailty, and there is additive joint effects of serum 25(OH)D and frailty on all-cause mortality in older adults.
机译：背景/目的：尽管脆弱和低维生素D分别与不良健康风险增加有关，但尚未报道它们对死亡率的综合影响。本研究前瞻性地研究了脆弱和维生素D状况对美国老年人死亡率的影响。受试者/方法：第三次全国健康与营养检查调查中60岁的参与者进行了12年的死亡率随访。 （n4731）。脆弱定义为满足三个或三个以上标准，脆弱前定义为满足五个脆弱标准中的一两个（低体重指数（BMI），缓慢行走，虚弱，疲惫和低体力活动）。维生素D的状态通过血清25-羟基维生素D（25（OH）D）进行评估，并分为四分位数。对性别，种族，年龄，吸烟，教育程度，纬度和其他合并症进行了分析。结果：体弱者的血清25（OH）D浓度最低，体弱者中的血清25（OH）D最高，而体弱者的血清25（OH）D最高。血清25（OH）D最低四分位数的脆弱几率是最高四分位数的几率的1.94倍（95％置信区间（CI）：1.09-3.44）。死亡率与体弱呈正相关，体弱且血清25（OH）D较低的参与者的风险显着高于非体弱且血清25（OH）D浓度高的参与者（危险比2.98; 95％CI：2.01-4.42）。结论：我们的结果表明，低血清25（OH）D与体弱相关，并且血清25（OH）D和体弱对老年人的全因死亡率具有累加联合作用。

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