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首页> 外文期刊>European journal of cancer prevention: The official journal of the European Cancer Prevention Organisation (ECP) >Prevention of carcinogen-induced mouse skin papilloma by whole fruit aqueous extract of Momordica charantia.
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Prevention of carcinogen-induced mouse skin papilloma by whole fruit aqueous extract of Momordica charantia.

机译：苦瓜全果水提取物预防致癌物诱导的小鼠皮肤乳头状瘤。

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摘要

The anticarcinogenic effect of aqueous extract of fruit of Momordica charantia (bitter gourd), which is widely used as a vegetable in India, was studied in a two-step skin carcinogenesis model in mice. The possible mode of action was also investigated. Oral administration of the fruit extract was found to have an adverse effect on the general health and lifespan of the animals when used at a high concentration. But when this dose was reduced by half, the test extract afforded protection from the development of skin tumour and increased life expectancy. Carcinogen-induced lipid peroxidation in liver and DNA damage in lymphocytes were found to be reduced following treatment with Momordica. The fruit extract was found to significantly activate the liver enzymes glutathione-S-transferase, glutathione peroxidase and catalase (P < 0.001), which showed a depression following exposure to the carcinogen. The results suggest a preventive role of water-soluble constituents of M. charantia fruit during carcinogenesis, which is mediated possibly by their modulatory effect on enzymes of the biotransformation and detoxification system of the host.
机译：在小鼠的两步皮肤致癌模型中，研究了苦瓜果实（苦瓜）的水提取物的抗癌作用，苦瓜果实在印度被广泛用作蔬菜。还研究了可能的作用方式。当以高浓度使用时，发现口服水果提取物对动物的总体健康和寿命有不利影响。但是，当该剂量减少一半时，测试提取物可保护皮肤肿瘤的发生并延长预期寿命。苦瓜处理后，降低了致癌物引起的肝脏脂质过氧化和淋巴细胞DNA损伤。水果提取物被发现可以显着激活肝脏酶谷胱甘肽-S-转移酶，谷胱甘肽过氧化物酶和过氧化氢酶（P <0.001），暴露于致癌物后会降低。结果表明，M。charantia果实的水溶性成分在致癌过程中具有预防作用，这可能是由于其对宿主生物转化和解毒系统酶的调节作用所介导的。

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