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首页> 外文期刊>European journal of paediatric neurology: EJPN : official journal of the European Paediatric Neurology Society >Intrathecal synthesis of anti-viral antibodies in pediatric patients.
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Intrathecal synthesis of anti-viral antibodies in pediatric patients.

机译：儿科患者鞘内合成抗病毒抗体。

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INTRODUCTION: Detection of intrathecal synthesis of specific antibodies (antibody index (AI)) is an established method to prove cerebral viral infection. Experience on its clinical application in large patient groups, however, is sparse. METHODS: Retrospective analysis of pediatric patients with positive viral AI treated at RWTH Aachen University Hospital between 1999 and 2005. RESULTS: 63 patients were studied, including 14 with encephalitis, 12 with neuritis, nine with cerebral vasculitis, six with multiple sclerosis (MS), five with severe cephalgia, five with psychiatric symptoms, three with hearing loss, two with seizures, three with white matter diseases, two with movement disorders, one with meningococcal meningitis and one with sinus venous thrombosis. Seven had several positive AI among them only one patient with MS. Of the 51 patients with a single positive AI and not having MS, 16 showed a positive AI for herpes simplex-, 13 for varicella zoster-, nine for Epstein-Barr-, four for cytomegalo-,four for mumps-, three for rubella- and two for measles virus. Frequent combinations were varicella zoster virus (VZV) and vasculitis (n = 8), herpes simplex virus (HSV) and neuritis (n = 6), Epstein-Barr virus (EBV) (n = 5), respectively, VZV (n = 4) and encephalitis as wells as mumps virus (n = 2) and hearing loss. Matched polymerase chain reaction (PCR) and AI data were available in 25 patients. PCR was simultaneously positive in three cases only. DISCUSSION: AI testing identifies a similar spectrum of pathogens as known from cerebrospinal fluid (CSF) PCR studies. It complements the PCR and increases the chance for adequate diagnosis and treatment of patients with assumed cerebral viral infections.
机译：引言：鞘内合成特定抗体（抗体指数（AI））的检测是证明脑病毒感染的既定方法。但是，其在大型患者群体中的临床应用经验很少。方法：回顾性分析亚琛工业大学附属医院于1999年至2005年间治疗的小儿病毒性AI阳性患者。结果：研究了63例患者，其中14例患有脑炎，12例患有神经炎，9例患有脑血管炎，6例患有多发性硬化症（MS） ，五例患有严重的头疼，五例具有精神症状，三例患有听力下降，二例患有癫痫，三例患有白质病，二例患有运动障碍，一例患有脑膜炎球菌性脑膜炎和一例患有窦性静脉血栓形成。七个中有几个AI阳性，其中只有一名MS患者。在51例单一AI阳性但无MS的患者中，有16例单纯疱疹阳性AI，13例水痘带状疱疹阳性，Epstein-Barr阳性9例，巨细胞病4例，腮腺炎4例，风疹3例-和两个麻疹病毒。常见的组合是水痘带状疱疹病毒（VZV）和血管炎（n = 8），单纯疱疹病毒（HSV）和神经炎（n = 6），爱泼斯坦-巴尔病毒（EBV）（n = 5），VZV（n = 4）脑炎以及腮腺炎病毒（n = 2）和听力损失。匹配的聚合酶链反应（PCR）和AI数据可用于25例患者。 PCR仅在三例中同时呈阳性。讨论：AI测试可以识别出与脑脊液（CSF）PCR研究相似的病原体。它补充了PCR，并增加了对假定的脑病毒感染患者进行充分诊断和治疗的机会。

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