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首页> 外文期刊>European journal of paediatric neurology: EJPN : official journal of the European Paediatric Neurology Society >Seizures and intellectual outcome: clinico-radiological study of 30 Egyptian cases of tuberous sclerosis complex.
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Seizures and intellectual outcome: clinico-radiological study of 30 Egyptian cases of tuberous sclerosis complex.

机译：癫痫发作和智力结果：30例埃及结节性硬化症病例的临床放射学研究。

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BACKGROUND AND OBJECTIVES: Tuberous sclerosis complex (TSC) is a multi-systemic disorder that involves primarily CNS, skin, kidney and heart. The aim of this study is to determine whether seizures type, interictal EEGs and tubers burden in MRI are correlated to seizure and intellectual outcome, and to identify the clinical risk factors for mental retardation and developing autism in these patients. METHODS: This was a prospective study that was conducted on 30 Egyptian children with tuberous sclerosis complex (TSC), diagnosed according to the criteria of National Institutes of Health consensus conference revised the diagnostic criteria for TSC. All patients underwent clinical and psychometric evaluation, interictal EEG, and MRI brain. RESULTS AND CONCLUSIONS: We found that poor intellectual outcome is related to early onset of seizures, infantile spasms, severely epileptogenic EEG findings and tuber burden on the Left side. Autistic behavior is related to seizure type (more with infantile spasms), severely epileptogenic EEG findings, frontal location of tubers and higher number of tubers (>8).
机译：背景与目的：结节性硬化症（TSC）是一种多系统性疾病，主要涉及中枢神经系统，皮肤，肾脏和心脏。这项研究的目的是确定MRI中的癫痫发作类型，发作间期脑电图和块茎负担是否与癫痫发作和智力结局相关，并确定这些患者智力低下和发展为自闭症的临床危险因素。方法：这是一项对30名埃及儿童结节性硬化症（TSC）进行的前瞻性研究，根据美国国立卫生研究院共识会议的标准诊断，修订了TSC的诊断标准。所有患者均接受了临床和心理评估，发作间脑电图和MRI脑。结果与结论：我们发现智力低下与癫痫发作，婴儿痉挛，严重致癫痫性脑电图发现和左侧块茎负担有关。自闭症的行为与癫痫发作类型有关（婴儿痉挛更多），严重的致癫痫性脑电图表现，块茎正面位置和块茎数量更多（> 8）。

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