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首页> 外文期刊>European journal of pediatrics >Cord-blood lipoproteins, homocysteine, insulin sensitivity/resistance marker profile, and concurrence of dysglycaemia and dyslipaemia in full-term neonates of the Mérida Study
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Cord-blood lipoproteins, homocysteine, insulin sensitivity/resistance marker profile, and concurrence of dysglycaemia and dyslipaemia in full-term neonates of the Mérida Study

机译：梅里达研究足月新生儿的脐带血脂蛋白，同型半胱氨酸，胰岛素敏感性/抵抗性标志物谱以及血糖异常和血脂异常的并发

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Early alterations in glucose homeostasis increase the risk of developing insulin resistance and obesity later in life. The concurrence of altered lipids and insulin sensitivity/resistance markers at birth has been scarcely investigated. The study aimed to ascertain level ranges of homocysteine (tHcyt), arylesterase (AE), lipids/lipoproteins, and insulin resistance/sensitivity markers in full-term neonates and to determine the concurrence effect of dyslipaemia and dysglycaemia on those parameters at birth. Participants were 197 full-term, 2.5 to <4.0 kg, without foetal distress Spanish newborns from the Mérida Study. Parameter percentiles for males and females were stated. The effect of the concurrence high glucose/high triglycerides (high glucose/high TG) or high glucose/low cholesterol transported by HDL (HDL-c) on tHcyt, LDL-c, HDL-c, lipoprotein (a) (Lp(a)), oxidised LDL (oxLDL), AE, glucose, insulin sensitivity (QUICKI) and insulin resistance index (HOMA-IR) was studied. Females had higher total cholesterol (TC), HDL-c, Apo A1, Lp(a) and HDL-c/Apo A1, but lower relative transport of TC (%TC) by the very low lipoprotein fraction than males. No gender differences were found for glucose, HOMA-IR and QUICKI. Neonates at the 2.5- to 2.999-kg range display more adequate HOMA-IR and QUICKI levels that their >3.0 kg counterparts. The concurrence of high glucose/high TG or high glucose/low HDL-c increased TC/HDL-c and HOMA-IR, but decreased, oxLDL, oxLDL/LDL-c and QUICKI with respect to that of low glucose/low TG or glucose/high HDL-c. The concurrence glucose/TG has predictive value for low QUICKI, whilst that of glucose/HDL-c for low QUICKI and high HOMA-IR, suggesting the importance of routine TG, HDL-c and glucose screening at birth as it would identify candidates for insulin resistance.
机译：葡萄糖稳态的早期改变增加了生命后期出现胰岛素抵抗和肥胖的风险。几乎没有研究过出生时脂质和胰岛素敏感性/抗性标志物改变的并发性。该研究旨在确定足月新生儿中同型半胱氨酸（tHcyt），芳基酯酶（AE），脂质/脂蛋白和胰岛素抵抗/敏感性标记物的水平范围，并确定血脂异常和血糖异常对出生时这些参数的同时影响。来自Mérida研究的197名足月婴儿（2.5至<4.0 kg）没有胎儿窘迫。说明了男性和女性的参数百分位数。 HDL（HDL-c）并发的高血糖/高甘油三酸酯（高血糖/高TG）或高血糖/低胆固醇对tHcyt，LDL-c，HDL-c，脂蛋白（a）（Lp（a ）），研究了氧化LDL（oxLDL），AE，葡萄糖，胰岛素敏感性（QUICKI）和胰岛素抵抗指数（HOMA-IR）。雌性的总胆固醇（TC），HDL-c，Apo A1，Lp（a）和HDL-c / Apo A1较高，但脂蛋白含量极低的TC相对运输（％TC）却比雄性低。葡萄糖，HOMA-IR和QUICKI均未发现性别差异。在2.5至2.999千克范围内的新生儿显示的HOMA-IR和QUICKI水平要高于其> 3.0千克的同类动物。高葡萄糖/高TG或高葡萄糖/低HDL-c的并发使TC / HDL-c和HOMA-IR升高，但相对于低葡萄糖/低TG或OXLDL，oxLDL / LDL-c和QUICKI降低葡萄糖/高HDL-c。并发的葡萄糖/ TG对低QUICKI具有预测价值，而葡萄糖/ HDL-c对低QUICKI和高HOMA-IR具有预测价值，这提示在出生时进行常规TG，HDL-c和葡萄糖筛查的重要性，因为它将确定候选人群。胰岛素抵抗。

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