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首页> 外文期刊>European journal of pediatrics >Feeding intolerance in preterm infants fed with powdered or liquid formula: A randomized controlled, double-blind, pilot study
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Feeding intolerance in preterm infants fed with powdered or liquid formula: A randomized controlled, double-blind, pilot study

机译：用粉末或液体配方食品喂养的早产儿的喂养不耐受：一项随机对照，双盲，先导研究

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Feeding intolerance (FI) is usually defined as "gastric residual volume of more than 50 % of the previous feeding volume, emesis, abdominal distension or both of these symptoms and a decrease, delay or discontinuation of enteral feedings." We aimed to compare the incidence of FI in preterm infants fed with powdered or liquid infant formula, and in a prospective, double-blind, pilot study, 78 preterm infants were randomized to receive powdered or liquid form of the same preterm infant formula. The primary outcomes were the incidence of FI in both groups. The pH of gastric fluids was measured in the fasting and postprandial periods on the seventh day of life, and gastrointestinal complications were recorded during the hospitalization period. The incidence of FI was significantly higher in infants fed with liquid formula (n=34) when compared with infants fed with powdered formula (n=44) [9 (26.5 %) vs 2 (4.5 %), p<0.01, respectively]. The median fasting gastric fluid pH was significantly lower and postprandial gastric fluid pH was significantly higher than in infants fed with powdered formula (2.9 vs 3.4, p<0.01 and 6.0 vs 5.9, p<0.05 respectively). Infants fed with liquid formula regained birth weight significantly later than infants fed with powdered formula (9.5 vs 8.0 days, p<0.01). Conclusion: Although the exact mechanisms are not clear, increased incidence of FI and delayed growth in the first weeks of life in preterm infants fed with liquid formula might be caused by altered gastric acidity or possible disrupted protein bioavailability due to different production and sterilization processes.
机译：喂养不耐受（FI）通常定义为“胃剩余量超过先前喂养量的50％，呕吐，腹胀或上述两种症状以及肠内喂养的减少，延迟或中断。”我们旨在比较用粉状或液体婴儿配方奶粉喂养的早产儿中FI的发生率，并且在一项前瞻性，双盲，先导研究中，有78名早产儿被随机分配接受相同粉状或液体形式的早产婴儿奶粉。主要结果是两组中FI的发生率。在生命的第七天，在禁食和餐后期间测量胃液的pH，并在住院期间记录胃肠道并发症。与以粉状配方食品（n = 44）喂养的婴儿相比，以液体配方食品（n = 34）喂养的婴儿的FI发生率显着更高[分别为9（26.5％）对2（4.5％），p <0.01]。 。与用粉状配方奶粉喂养的婴儿相比，空腹胃液的中位pH显着降低，餐后胃液pH显着升高（分别为2.9 vs 3.4，p <0.01和6.0 vs 5.9，p <0.05）。饲喂液态配方奶粉的婴儿的出生体重显着晚于饲喂配方奶粉的婴儿（9.5 vs 8.0天，p <0.01）。结论：尽管确切的机理尚不清楚，但由于不同的生产和灭菌过程，胃酸度改变或蛋白质生物利用度可能破坏，可能导致早产儿口服液体配方奶粉时FI发生率增加和生长迟缓。

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