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首页> 外文期刊>International Materials Reviews >Role of materials surface topography on mammalian cell response
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Role of materials surface topography on mammalian cell response

机译：材料表面形貌在哺乳动物细胞反应中的作用

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Many approaches are used to modify the surface topography of implant materials. Some produce unordered surfaces using, for example, classical implant surface treatments, whereas others produce ordered surfaces by micro- and nanopatterning techniques. Surface topographies can be characterised by several methods that can acquire two-dimensional profiles or three-dimensional measurements and calculate different roughness parameters. The importance of using systematically several roughness parameters for correlation with biological response, and of consider these parameters at different scales will be demonstrated. Furthermore, it will be described, from a general point of view, how cells are able to identify and respond to surface topography. The role of membrane receptors, cytoskeleton, filopods and intracellular signal transduction in the response to topography will be considered and discussed. A critical review of more than 300 papers provides the basis for illustrating how mammalian cells respond to surface topography and how their rugophilia, the increased cell response to rougher surfaces, is a function of cell phenotype. For the first time, the rugophilia of cells from different tissue origins is compared in a synthetic table.
机译：许多方法用于修改植入物材料的表面形貌。一些使用例如经典的植入物表面处理产生无序的表面，而另一些通过微图案和纳米图案化技术产生有序的表面。表面形貌可以通过几种方法来表征，这些方法可以获取二维轮廓或三维测量值并计算不同的粗糙度参数。将证明系统地使用几个粗糙度参数与生物学响应相关以及在不同规模下考虑这些参数的重要性。此外，将以一般的观点来描述细胞如何能够识别和响应表面形貌。将考虑并讨论膜受体，细胞骨架，丝足和细胞内信号转导在地形响应中的作用。一篇超过300篇论文的重要评论为说明哺乳动物细胞如何响应表面形貌以及它们的嗜细胞性（即对粗糙表面的增强细胞响应）是细胞表型的函数奠定了基础。首次在合成表中比较了来自不同组织来源的细胞的嗜性。

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