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首页> 外文期刊>European journal of gastroenterology and hepatology >Early increase of lower oesophageal sphincter pressure after band ligation of oesophageal varices in cirrhotics: an intriguing phenomenon.
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Early increase of lower oesophageal sphincter pressure after band ligation of oesophageal varices in cirrhotics: an intriguing phenomenon.

机译：肝硬化食管静脉曲张带结扎后，早期食管下括约肌压力的早期升高：一种有趣的现象。

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AIM: We conducted a prospective, randomized comparison of endoscopic variceal ligation, sclerotherapy and metoclopramide injection in order to evaluate their early effect on lower oesophageal sphincter pressure. METHODS: Twenty-six patients with established cirrhosis and an episode of variceal bleeding controlled by one session of endoscopic therapy were randomized to undergo an oesophageal manometry. The patients' lower oesophageal sphincter pressure was evaluated, prior to and immediately after a single session of ligation (n = 10), a single session of sclerotherapy (n = 8) or a bolus injection of 20 mg metoclopramide hydrochloride (n = 8). RESULTS: Ligation produced a higher early increase in lower oesophageal sphincter pressure (from 12.3 +/- 2.3 to 27.8 +/- 3.0 mmHg) as compared with sclerotherapy (from 13.6 +/- 2.5 to 22.4 +/- 4.5 mmHg) or metoclopramide injection (from 14.6 +/- 3.2 to 22.5 +/- 2.9 mmHg); (P = 0.0001). CONCLUSION: Our data indicate that ligation of oesophageal varices produces anearly increase in lower oesophageal sphincter pressure in cirrhotic patients.
机译：目的：我们对内镜下静脉曲张结扎，硬化治疗和甲氧氯普胺注射液进行了前瞻性，随机比较，以评估其对降低食管括约肌压力的早期作用。方法：将26例肝硬化并经一次内镜治疗控制的静脉曲张破裂出血患者随机分配接受食管测压。在单次结扎（n = 10），单次硬化疗法（n = 8）或大剂量注射20 mg盐酸甲氧氯普胺之前或之后立即评估患者的食管下括约肌压力。结果：与硬化疗法（从13.6 +/- 2.5到22.4 +/- 4.5 mmHg）或甲氧氯普胺注射相比，结扎可降低食管括约肌的早期压力（从12.3 +/- 2.3到27.8 +/- 3.0 mmHg）。 （从14.6 +/- 3.2到22.5 +/- 2.9 mmHg）; （P ＝ 0.0001）。结论：我们的数据表明，肝硬化患者食管静脉曲张结扎可导致食管下括约肌压力降低。

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