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首页> 外文期刊>European journal of gastroenterology and hepatology >In through the out door: serology for atrophic gastritis.
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In through the out door: serology for atrophic gastritis.

机译：从外面进来：萎缩性胃炎的血清学检查。

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摘要

Gastric cancer remains the second biggest cause of cancer death worldwide. The most common type of gastric cancer, the intestinal type, is usually preceded by chronic atrophic gastritis. Gastritis serology is therefore of crucial importance for population-based screening and prevention studies. Helicobacter pylori serum antibodies can adequately diagnose inflammation of the gastric mucosa, but the serological diagnosis of atrophic gastritis is more hazardous. Many tests have been used for this purpose, either alone or in various combinations. Depending on the population, pepsinogens and gastrin often have a high specificity but low sensitivity for the diagnosis of atrophic gastritis, whereas antibodies against H. pylori or CagA have a high sensitivity but low specificity. A combination of two tests, e.g. H. pylori antibodies and pepsinogen I, may balance this issue and provide adequate screening tools, although there is a clear need for further improvement and simplification of serological testing for atrophic gastritis.
机译：胃癌仍然是全世界癌症死亡的第二大原因。胃癌最常见的类型是肠道类型，通常先于慢性萎缩性胃炎。因此，胃炎血清学对于基于人群的筛查和预防研究至关重要。幽门螺杆菌血清抗体可以充分诊断胃粘膜炎症，但是血清学诊断萎缩性胃炎则更加危险。为此，已经单独或以多种组合使用了许多测试。视人群而定，胃蛋白酶原和胃泌素通常对萎缩性胃炎的诊断具有高特异性但敏感性低，而针对幽门螺杆菌或CagA的抗体具有高敏感性但特异性低。两种测试的组合，例如尽管明显需要进一步改善和简化萎缩性胃炎的血清学检测，但是幽门螺杆菌抗体和胃蛋白酶原I可以平衡这个问题并提供足够的筛选工具。

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