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首页> 外文期刊>European journal of gastroenterology and hepatology >Influence of gastritis on cyclooxygenase-2 expression before and after eradication of Helicobacter pylori infection.
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Influence of gastritis on cyclooxygenase-2 expression before and after eradication of Helicobacter pylori infection.

机译：根除幽门螺杆菌感染前后胃炎对环氧合酶2表达的影响。

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OBJECTIVES: Helicobacter pylori infection causes chronic gastritis and induces cyclooxygenase (COX)-2 expression. The relationship between gastritis and COX-2 expression is not well understood, especially long after the organism has been eradicated. We designed a study to elucidate this relationship. METHODS: Four endoscopic gastric biopsies from each of 118 H. pylori-infected subjects were assessed for COX-2 expression immunohistochemically, gastritis, by an updated Sydney System. In the 107 successfully eradicated subjects, the assessment was repeated once yearly, for 3 years. RESULTS: After successful eradication, COX-2 expression was reduced significantly regardless of site. Atrophy improved significantly and intestinal metaplasia improved but not in the antrum greater curvature. After 1 year COX-2 expression was not significantly different in the epithelia with and without intestinal metaplasia. Correlation between COX-2 expression and neutrophil score in the antrum (r = 0.214, P = 0.042) and inflammation in the corpus (r = 0.234, P = 0.025) disappeared after eradication. COX-2 expression correlated well with atrophy and metaplasia before and after eradication. No significant reduction in COX-2 or improvement in gastritis was found in subjects with eradication failure. CONCLUSION: H. pylori infection is associated with the enhancement of COX-2 expression in the gastric mucosa. Eradication therapy reduces COX-2 expression and hence may reduce the risk of cancer development.
机译：目的：幽门螺杆菌感染可引起慢性胃炎并诱导环氧合酶（COX）-2的表达。胃炎与COX-2表达之间的关系尚未得到很好的理解，尤其是在根除该微生物后很长时间。我们设计了一项研究来阐明这种关系。方法：通过更新的悉尼系统，从118例幽门螺杆菌感染的受试者中的每人进行了四次内镜胃活检，通过免疫组化，胃炎评估了COX-2表达。在成功消灭的107位受试者中，每年重复评估一次，为期3年。结果：成功根除后，无论位于何处，COX-2的表达均明显降低。萎缩明显改善，肠上皮化生改善，但胃窦大曲率没有改善。 1年后，有无肠上皮化生的上皮中COX-2的表达无明显差异。根除后，胃中COX-2表达与嗜中性白细胞评分（r = 0.214，P = 0.042）和and体炎症（r = 0.234，P = 0.025）之间的相关性消失了。根除前后，COX-2表达与萎缩和化生关系密切。在根除失败的受试者中未发现COX-2显着降低或胃炎改善。结论：幽门螺杆菌感染与胃黏膜中COX-2表达的增强有关。根除疗法可降低COX-2的表达，因此可降低癌症发展的风险。

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