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首页> 外文期刊>European journal of gastroenterology and hepatology >Long-term follow-up of empirical treatment or prompt endoscopy for patients with persistent dyspeptic symptoms?
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Long-term follow-up of empirical treatment or prompt endoscopy for patients with persistent dyspeptic symptoms?

机译：对持续存在消化不良症状的患者进行长期的经验治疗或及时内镜检查？

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BACKGROUND: There are concerns about the safety and possible high costs of ongoing proton pump inhibitor therapy of empirical management strategies for patients with persistent dyspeptic symptoms. AIM: To compare the long-term results of two treatment strategies: empirical treatment followed by the Helicobacter pylori test and treat strategy (treat and test group) and prompt upper gastrointestinal endoscopy followed by directed medical treatment (endoscopy group). METHODS: In this study we describe the long-term follow-up data from a previously published randomized clinical trial. At least 6 years after randomization all participating general practitioners and patients were asked to give information about medication use, diagnostic testing, symptoms and quality of life by questionnaire. RESULTS: Information about a total of 77 out of the 80 patients initially included (96%) was retrieved. Overall, 16 patients from the treat and test group (41%) underwent 18 diagnostic investigations. The 34 patients (100%) from the endoscopy group underwent 38 investigations (P < 0.01). The number of patients of the treat and test group and endoscopy group using acid inhibition therapy was 15 (38%) and 19 (56%), respectively (P = 0.14). There were also no differences in symptom prevalence and quality of life between the groups. CONCLUSIONS: Treat and test management for patients with dyspeptic symptoms is safe and does not lead to additional diagnostic testing or use of medication when compared to prompt endoscopy.
机译：背景：对于持续存在消化不良症状的患者，对正在进行的经验管理策略进行质子泵抑制剂治疗的安全性和可能产生的高额费用存在担忧。目的：比较两种治疗策略的长期结果：经验治疗，然后进行幽门螺杆菌测试和治疗策略（治疗和测试组），及时进行上消化道内镜检查，然后进行定向医疗（内镜检查组）。方法：在这项研究中，我们描述了来自先前发表的随机临床试验的长期随访数据。随机分组后至少6年，要求所有参与调查的全科医生和患者通过问卷调查提供有关药物使用，诊断测试，症状和生活质量的信息。结果：检索到最初纳入的80例患者中总共77例（96％）的信息。总体而言，治疗和测试组的16名患者（41％）接受了18次诊断研究。内镜组的34例患者（100％）接受了38项检查（P <0.01）。使用酸抑制疗法的治疗和测试组以及内窥镜检查组的患者数分别为15（38％）和19（56％）（P = 0.14）。两组之间的症状患病率和生活质量也没有差异。结论：对于消化不良症状的患者进行治疗和测试管理是安全的，与及时内镜检查相比，不会导致额外的诊断测试或药物治疗。

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