• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of gastroenterology and hepatology >Gastro-oesophageal reflux disease, reflux oesophagitis and non-erosive reflux disease in a multiracial Asian population: a prospective, endoscopy based study.
【24h】

Gastro-oesophageal reflux disease, reflux oesophagitis and non-erosive reflux disease in a multiracial Asian population: a prospective, endoscopy based study.

机译：亚洲多种族人群的胃食管反流疾病，反流性食管炎和非糜烂性反流疾病：一项基于内镜的前瞻性研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To determine the prevalence of and risk factors for gastro-oesophageal reflux disease (GORD), reflux oesophagitis and non-erosive reflux disease (NERD) amongst Malaysian patients undergoing upper gastrointestinal endoscopic examination. DESIGN: A cross-sectional study on consecutive patients with dyspepsia undergoing upper gastrointestinal endoscopy. SETTING: A large general hospital in Kuala Lumpur, Malaysia. PARTICIPANTS: Consecutive patients undergoing endoscopy for upper abdominal discomfort were examined for the presence of reflux oesophagitis, hiatus hernia and Barrett's oesophagus. The diagnosis and classification of reflux oesophagitis was based on the Los Angeles classification. Patients with predominant symptoms of heartburn or acid regurgitation of at least one per month for the past 6 months in the absence of reflux oesophagitis were diagnosed as having NERD. The prevalence of GORD, reflux oesophagitis and NERD were analysed in relation to age, gender, race, body mass index (BMI), presence of hiatus hernia, Helicobacter pylori status, alcohol intake, smoking and level of education. RESULTS: One thousand patients were studied prospectively. Three hundred and eighty-eight patients (38.8%) were diagnosed as having GORD based on either predominant symptoms of heartburn and acid regurgitation and/or findings of reflux oesophagitis. One hundred and thirty-four patients (13.4%) had endoscopic evidence of reflux oesophagitis. Two hundred and fifty-four (65.5%) were diagnosed as having NERD. Hiatus hernia was found in 6.7% and Barrett's oesophagus in 2% of patients. Of our patients with reflux oesophagitis 20.1% had grade C and D oesophagitis. No patients had strictures. Following logistic regression analysis, the independent risk factors for GORD were Indian race (odds ratio (OR), 3.25; 95% confidence interval (CI), 2.38-4.45), Malay race (OR, 1.67; 95% CI, 1.16-2.38), BMI > 25 (OR, 1.41; 95% CI, 1.04-1.92), presence of hiatus hernia (OR, 4.21; 95% CI, 2.41-7.36), alcohol consumption (OR, 2.42; 95% CI, 1.11-5.23) and high education level (OR, 1.52; 95% CI, 1.02-2.26). For reflux oesophagitis independent the risk factors male gender (OR, 1.64; 95% CI, 1.08-2.49), Indian race (OR, 3.25; 95% CI, 2.05-5.17), presence of hiatus hernia (OR, 11.67; 95% CI, 6.40-21.26) and alcohol consumption (OR, 3.22; 95% CI, 1.26-8.22). For NERD the independent risk factors were Indian race (OR, 3.45; 95% CI, 2.42-4.92), Malay race (OR, 1.80; 95% CI, 1.20-2.69), BMI > 25 (OR, 1.47; 95% CI, 1.04, 2.06) and high education level (OR, 1.66; 95% CI, 1.06-2.59). CONCLUSIONS: Reflux oesophagitis and Barrett's oesophagus were not as uncommon as previously thought in a multiracial Asian population and a significant proportion of our patients had severe grades of reflux oesophagitis. NERD, however, still constituted the larger proportion of patients with GORD. Indian race was consistently a significant independent risk factor for reflux oesophagitis, NERD and for GORD overall.
机译：目的：确定接受上消化道内窥镜检查的马来西亚患者的胃食管反流病（GORD），反流性食管炎和非糜烂性反流病（NERD）的患病率和危险因素。设计：一项连续消化不良患者接受上消化道内窥镜检查的横断面研究。地点：马来西亚吉隆坡的一家大型综合医院。研究对象：连续接受内镜检查的上腹部不适患者，检查是否存在反流性食管炎，裂孔疝和巴雷特食管。反流性食管炎的诊断和分类基于Los Angeles分类。在没有反流性食管炎的情况下，在过去6个月中，每月有至少1次每月至少有一次烧心或胃酸反流的主要症状的患者被诊断为NERD。分析了GORD，反流性食管炎和NERD的患病率，并与年龄，性别，种族，体重指数（BMI），裂孔疝的存在，幽门螺杆菌状态，饮酒，吸烟和受教育程度相关。结果：前瞻性研究了1000例患者。根据胃灼热和胃酸反流的主要症状和/或反流性食管炎的发现，有388位患者（38.8％）被诊断为GORD。内窥镜检查有134例患者（占13.4％）有反流性食管炎的证据。 254名（65.5％）被诊断为NERD。在6.7％的患者中发现了裂孔疝，在2％的患者中发现了巴雷特食管。在我们的反流性食管炎患者中，有20.1％患有C级和D级食管炎。没有患者有狭窄。经过logistic回归分析后，GORD的独立危险因素是印度种族（优势比（OR）为3.25; 95％置信区间（CI）为2.38-4.45），马来种族（OR为1.67; 95％CI为1.16-2.38） ），BMI> 25（OR，1.41; 95％CI，1.04-1.92），存在裂孔疝（OR，4.21; 95％CI，2.41-7.36），饮酒（OR，2.42; 95％CI，1.11- 5.23）和较高的教育水平（OR为1.52; 95％CI为1.02-2.26）。对于独立于反流性食管炎的危险因素，男性（OR，1.64; 95％CI，1.08-2.49），印度裔（OR，3.25; 95％CI，2.05-5.17），有裂孔疝（OR，11.67; 95％） CI，6.40-21.26）和酒精消耗量（OR，3.22; 95％CI，1.26-8.22）。 NERD的独立危险因素是印度种族（OR，3.45; 95％CI，2.42-4.92），马来种族（OR，1.80; 95％CI，1.20-2.69），BMI> 25（OR，1.47; 95％CI ，1.04、2.06）和较高的教育水平（OR为1.66; 95％CI为1.06-2.59）。结论：在亚洲多种族人群中，反流性食管炎和巴雷特食管并没有以前所认为的罕见，而且我们的患者中有很大一部分患有严重的反流性食管炎。然而，NERD在GORD患者中仍占较大比例。印度种族一直是反流性食管炎，NERD和整个GORD的重要独立危险因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号