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首页> 外文期刊>European journal of gastroenterology and hepatology >Two cases of spontaneous regression of multicentric hepatocellular carcinoma after intraperitoneal rupture: possible role of immune mechanisms.
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Two cases of spontaneous regression of multicentric hepatocellular carcinoma after intraperitoneal rupture: possible role of immune mechanisms.

机译：腹膜内破裂后多发性多发性肝细胞癌的两例自发消退：免疫机制的可能作用。

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We report two cases of spontaneous regression of hepatocellular carcinoma. Firstly, a 64-year-old man with alcohol related cirrhosis developed multiple liver tumours with elevation of the alpha-fetoprotein level at 915 ng/ml. A spontaneous regression of all the tumoural masses but one and normalization of the alpha-fetoprotein level was observed after intraperitoneal spread of the malignancy. Resection of the remaining tumour 9 months later confirmed a hepatocellular carcinoma. Secondly, a 70-year-old woman with alcohol related cirrhosis developed multiple liver tumours with elevation of the alpha-fetoprotein level to 4000 ng/ml; a regression of all the tumoural masses but one and a decrease of the alpha-fetoprotein level to 400 ng/ml was observed after intraperitoneal spread of the malignancy and treatment with tamoxifen. We discuss a possible immune mechanism of tumoural regression with a review of similar cases described in the literature.
机译：我们报告了两例肝细胞癌自发性消退的情况。首先，一名患有酒精相关性肝硬化的64岁男性患上了多个肝肿瘤，甲胎蛋白水平升高至915 ng / ml。腹膜内扩散恶性肿瘤后，所有肿瘤肿块均自发消退，但甲肿瘤蛋白水平正常。 9个月后切除剩余的肿瘤，确认为肝细胞癌。其次，一名患有酒精相关性肝硬化的70岁女性患上了多个肝肿瘤，甲胎蛋白水平升高至4000 ng / ml。在腹膜内扩散恶性肿瘤并用他莫昔芬治疗后，观察到所有肿瘤块均消退，但其中一个甲胎蛋白水平降低至400 ng / ml。我们讨论了文献中描述的类似病例，探讨了肿瘤消退的可能的免疫机制。

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