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首页> 外文期刊>European journal of gastroenterology and hepatology >Intestinal infection and irritable bowel syndrome.
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Intestinal infection and irritable bowel syndrome.

机译：肠感染和肠易激综合症。

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摘要

The observation that the symptoms of irritable bowel syndrome (IBS) in some patients might follow an episode of acute gastroenteritis came from epidemiological studies. Both retrospective and prospective studies suggest that between 4% and 26% of patients develop IBS for the first time after gastroenteritis. The diagnosis of post-infectious IBS is typically made from the history. In addition, as with the diagnosis of IBS more generally, it is important to exclude other clinical causes for persistent bowel dysfunction. There is little, if any, evidence to support the widely-held view that patients with post-infectious IBS carry a better prognosis than IBS patients more generally. The management of patients with post-infectious IBS is the standard approach that might be applied to all patients with IBS. Post-infectious IBS patients may differ from IBS patients in general in having a low-level of intestinal inflammation. Work in animal models, and detection of low-grade inflammation in intestinal biopsiescombined with markers of intestinal inflammation such as faecal calprotectin all indicate a strong possibility that persisting inflammation after the acute infection may be important in the pathogenesis of post-infectious IBS.
机译：流行病学研究表明，某些患者肠易激综合征（IBS）的症状可能在急性胃肠炎发作后出现。回顾性研究和前瞻性研究均表明，肠胃炎后首次出现IBS的患者占4％至26％。感染后IBS的诊断通常是根据病史进行的。此外，与更广泛的IBS诊断一样，重要的是要排除其他持续性肠功能障碍的临床原因。几乎没有证据支持这种普遍观点，即感染后IBS患者的预后要比IBS患者更普遍。感染后IBS患者的治疗是可能适用于所有IBS患者的标准方法。感染后IBS患者的肠道炎症水平可能与IBS患者有所不同。在动物模型中工作，以及在肠道活检组织中检测到低度炎症，并结合肠道炎症标记物（如粪便钙卫蛋白），都表明在急性感染后持续炎症可能在感染后IBS的发病机制中很重要。

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