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首页> 外文期刊>European journal of gastroenterology and hepatology >Partial splenic embolization as pretreatment for antiviral therapy in hepatitis C virus infection.
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Partial splenic embolization as pretreatment for antiviral therapy in hepatitis C virus infection.

机译：部分脾栓塞术作为丙型肝炎病毒感染抗病毒治疗的预处理。

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摘要

Chronic hepatitis C virus infection is frequently complicated by cirrhosis and hypersplenism, which together with several other factors, such as reduced thrombopoietin synthesis in the liver, cause cytopenia. The antiviral combination therapy with pegylated interferon and ribavirin itself is impaired by haematological toxicity. Partial splenic embolization (PSE) by the injection of microspheres via a catheter comprising approximately 30-70% of the splenic parenchyma is now a safe method, which significantly reduces the cytopenia induced by hypersplenism, especially thrombocytopenia. The effect is long lasting up to 20 years and has been documented in a variety of disorders. PSE is now carefully described in a combination modality as a pretreatment to reduce cytopenia in hepatitis C virus-induced cirrhosis patients with hypersplenism, making antiviral therapy possible per se at higher dosages with a sustained duration.
机译：慢性丙型肝炎病毒感染常并发肝硬化和脾功能亢进，并与其他几种因素（例如肝脏中血小板生成素合成减少）一起导致血细胞减少症。聚乙二醇化干扰素和利巴韦林本身的抗病毒联合治疗受到血液学毒性的损害。现在，通过包含约30-70％脾实质的导管注射微球进行部分脾栓塞术（PSE）是一种安全的方法，该方法可显着减少脾功能亢进引起的血细胞减少症，尤其是血小板减少症。该作用持续长达20年，并且已在多种疾病中得到证明。现在，PSE在组合方式中已被认真描述为减少丙型肝炎病毒诱发的脾功能亢进的肝硬化患者血细胞减少症的预处理方法，从而使高剂量的抗病毒治疗本身成为可能，并且持续持续时间。

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