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首页> 外文期刊>European journal of gynaecological oncology >Nuclear alterations of cells and atypical metaplastic cells in cervical smears are predictive criteria of high-grade cervical intraepithelial neoplasia.
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Nuclear alterations of cells and atypical metaplastic cells in cervical smears are predictive criteria of high-grade cervical intraepithelial neoplasia.

机译：宫颈涂片中细胞和非典型化生细胞的核改变是高级宫颈上皮内瘤变的预测标准。

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摘要

Diagnoses based on the screening of cervical smears show low interobserver reproducibility and are frequently discordant with the final histological diagnosis. The aim of this study was to identify which of the cytomorphologic criteria used in the screening of cervical smears were most predictive of the histopathological grades of cervical intraepithelial neoplasia. The abnormal cervical smears of 206 women were reviewed blindly according to 22 pre-established cytomorphological criteria. Colposcopic evaluation was carried out in all cases. The marked presence of several nuclear criteria frequently found together in the same smear was associated with high grade intraepithelial neoplasia regardless of the presence of any other criteria. On the other hand, when the nuclear criteria were less evident, the cluster of criteria related to metaplastic cells was predictive of a diagnosis of high-grade intraepithelial neoplasia. Focusing on selected cytological criteria can aggregate predictive value to cervicalsmear diagnoses.
机译：基于宫颈涂片筛查的诊断显示观察者间的可重复性低，并且常常与最终的组织学诊断不一致。这项研究的目的是确定用于筛查宫颈涂片的哪种细胞形态学标准最能预测宫颈上皮内瘤变的组织病理学等级。根据22个预先建立的细胞形态学标准，盲目检查了206名妇女的异常宫颈涂片。在所有情况下均进行阴道镜评估。不管是否存在其他任何标准，在同一涂片中经常一起发现的几种核标准的明显存在与高度上皮内瘤变相关。另一方面，当核标准不那么明显时，与化生细胞相关的标准簇可预示诊断为高度上皮内瘤变。专注于选定的细胞学标准可以为宫颈涂片诊断积累预测价值。

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