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首页> 外文期刊>European journal of gynaecological oncology >Role of human papillomavirus testing in reducing the number of surgical treatments for precancerous cervical lesions.
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Role of human papillomavirus testing in reducing the number of surgical treatments for precancerous cervical lesions.

机译：人乳头瘤病毒测试在减少宫颈癌前病变的手术治疗中的作用。

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PURPOSE OF INVESTIGATION: To determine whether the addition of the Hybrid Capture II (HC II) test (Digene Corp., Gaithersburg, MD, USA) to cytological, colposcopical and histological results could reduce the number of surgical treatment procedures for precancerous cervical lesions. METHODS: Surgical treatment of precancerous cervical lesions was performed in 181 women. Priorly, the women were tested for high-risk human papillomavirus (HPV). Sensitivity, specificity, positive and negative predictive value were calculated to assess the performance characteristics of HC II in the detection of cervical intraepithelial neoplasia grade 2 or worse (CIN 2+) and grade 3 or worse (CIN 3+). RESULTS: Eighty (44.2%) women had a histological result < CIN 2; 117 (64.6%) women had < CIN 3. Fifty-three (29.3%) women with < CIN 2 tested HPV negative; 69 (38.1%) women with < CIN 3 tested HPV negative (p < 0.05). The sensitivity of HC II for detecting CIN 2+ and CIN 3+ was 76.2% and 87.5%, respectively. CONCLUSION: A highproportion of women were overtreated probably due to cytological and histological overestimations. HPV testing would reduce the number of unnecessary surgical treatments and should be used as an additional screening tool.
机译：调查的目的：为了确定是否在细胞学，阴道镜和组织学检查结果中增加Hybrid Capture II（HC II）测试（Digene Corp.，盖瑟斯堡，马里兰州，美国）是否可以减少宫颈癌前病变的外科治疗程序数量。方法：对181例女性宫颈癌前病变进行了手术治疗。此前，这些妇女接受过高危人类乳头瘤病毒（HPV）测试。计算敏感性，特异性，阳性和阴性预测值，以评估HC II在检测宫颈上皮内瘤样变2级或更差（CIN 2+）和3级或更差（CIN 3+）时的性能特征。结果：80名（44.2％）妇女的组织学结果

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