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首页> 外文期刊>European journal of gynaecological oncology >Lymph node sampling is of prognostic value in early stage epithelial ovarian carcinoma.
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Lymph node sampling is of prognostic value in early stage epithelial ovarian carcinoma.

机译：淋巴结取样对早期上皮性卵巢癌具有预后价值。

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PURPOSE: The importance of lymph node involvement as a prognostic factor is still under debate. In the present study, the impact of surgical staging for prognosis in early stages of epithelial ovarian cancer was evaluated in a series of 113 patients. MATERIAL AND METHODS: A retrospective study was carried out at the Department of Gynecological Oncology, Orebro University Hospital, during the period 1994-1998. In a subgroup of 20 out of 113 patients, pelvic lymph node sampling or pelvic lymphadenectomy was included in the standard surgical procedure. In cases of positive lymph nodes, the tumors were upstaged to FIGO Stage III. Pearson's chi-square, the t-test, the log-rank test and Cox multivariate analysis were used in the statistical analyses. RESULTS: The 20 patients with lymph node sampling or lymphadenectomy were compared with the remaining 93 patients without a comprehensive surgical staging procedure. A survival analysis demonstrated a significant (p = 0.005) difference in disease-free survival rates between the two subgroups, where there was a survival benefit in the subgroup of patients who had undergone comprehensive surgical staging. In a Cox proportional hazard regression analysis with disease-free survival as the endpoint, high tumor grade (HR = 3.14) and comprehensive surgical staging with at least a node sampling (HR = 0.09) were significant and independent prognostic factors. CONCLUSION: The benefit in survival after the procedure of lymph node sampling in early stages of epithelial ovarian carcinoma could probably be explained by the fact that the surgical procedure detects otherwise unrecognized Stage III disease.
机译：目的：淋巴结受累作为预后因素的重要性仍在争论中。在本研究中，在113例患者中评估了手术分期对上皮性卵巢癌早期阶段的预后的影响。材料与方法：回顾性研究于1994-1998年间在厄勒布鲁大学医院妇科肿瘤科进行。在113名患者中的20名亚组中，标准的外科手术包括盆腔淋巴结取样或盆腔淋巴结清扫术。在淋巴结阳性的情况下，将肿瘤升级到FIGO III期。在统计分析中使用了皮尔逊卡方检验，t检验，对数秩检验和Cox多元分析。结果：将20例行淋巴结取样或淋巴结清扫术的患者与其余93例未经综合手术分期程序的患者进行了比较。生存分析表明，两个亚组之间的无病生存率存在显着差异（p = 0.005），其中接受了全面手术分期的患者亚组具有生存优势。在以无病生存期为终点的Cox比例风险回归分析中，高肿瘤分级（HR = 3.14）和至少有淋巴结取样（HR = 0.09）的综合手术分期是重要且独立的预后因素。结论：上皮性卵巢癌早期淋巴结取样后对生存的益处可能是由于手术方法检测到了其他无法识别的III期疾病这一事实所致。

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