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首页> 外文期刊>European journal of gynaecological oncology >Koilocytosis and squamous (pre)neoplasia as detected in population-based cervical screening: practice and theory.
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Koilocytosis and squamous (pre)neoplasia as detected in population-based cervical screening: practice and theory.

机译：在基于人群的子宫颈筛查中发现的小细胞增多症和鳞状（前）neoplasia：实践和理论。

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INTRODUCTION: Koilocytosis (cavitation of the cytoplasm due to active HPV infection) can be detected in the screening process for cervical carcinoma. OBJECTIVE: To report the practice of detection of koilocytosis and (pre)neoplasia in population screening and to exploit the collected data to propose an explanation for the relationship between HPV infection and nuclear precancerous changes. STUDY DESIGN: Centrally collected and stored (SBBW, Leiden, the Netherlands) data from all smears of six regional pathology laboratories (1995-2002), coded according to KOPAC (the national cervical smear coding system; S1: normal thru S9: invasive carcinoma) were accessed. Prevalences per 100,000 smears were calculated for koilocytosis and for squamous abnormalities after stratification for country of origin of screenees. The relative risk (RR) for the ethnic (age) groups was computed by dividing the prevalence of the relevant ethnic (age) group by the prevalence of all women. RESULTS: Surinamese women featured the highest prevalence of koilocytosis and of all squamous abnormalities. Moroccan women the lowest. The RR for koilocytosis was highest at 30 years (1.84) and lowest at 60 (0.26). RR dependence on age of S5-S9 lesions was similar. Compared to nonkoilocytotic smears, koilocytosis was 104 times more frequent in the 1,500 S4 smears, 36x more frequent in the 6,700 S2-S3 smears, and 24x more frequent in the 1,740 S5-S9 smears. In all three categories this difference is statistically significant. CONCLUSION: High prevalences for both koilocytosis and for preneoplasia were detected in Surinamese immigrants, however, it still does not exclude HPV infection as a confounder linked to sexual lifestyle. The presence of koilocytosis in cervical smears may serve to identify patients with an increased risk for cervical cancer and perhaps warrant more intensive surveillance than what is provided through five-yearly screening.
机译：引言：在宫颈癌的筛查过程中可以检测到白细胞增多症（由于活跃的HPV感染导致细胞质空化）。目的：报告在人群筛查中检测白细胞增多症和（前）neoplasia的实践，并利用收集的数据为HPV感染与核癌前变化之间的关系提供解释。研究设计：根据KOPAC（国家宫颈涂片编码系统; S1：正常至S9：浸润性癌），从六个区域病理实验室（1995-2002）的所有涂片集中收集和存储（SBBW，荷兰莱顿）数据。 ）被访问。对于筛查对象的原籍国，对分层后的白细胞增多症和鳞状异常计算出每100,000个涂片的患病率。通过将相关种族（年龄）群体的患病率除以所有妇女的患病率，可以计算出种族（年龄）群体的相对风险（RR）。结果：苏里南妇女的白细胞增多症和所有鳞状异常的患病率最高。摩洛哥妇女最低。单核细胞增多症的RR最高为30年（1.84），最低为60（0.26）。 RR对S5-S9病变年龄的依赖性相似。与非粒细胞性涂片相比，在1500个S4涂片中，白细胞增多症的发生频率高104倍，在6700个S2-S3涂片中，粒细胞增多的频率高36倍，而在1,740个S5-S9涂片中频率高的24倍。在所有三个类别中，此差异在统计上都是显着的。结论：在苏里南移民中发现了高的白细胞增多症和neopoplasia患病率，但是，它仍不排除HPV感染是与性生活方式有关的混杂因素。子宫颈细胞涂片中存在小细胞增多症可能有助于确定患子宫颈癌风险增加的患者，并且可能需要比五年一次筛查提供的更深入的监测。

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