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首页> 外文期刊>European journal of gynaecological oncology >Expression of matrix metalloproteinase-2 in preinvasive and invasive carcinoma of the uterine cervix.
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Expression of matrix metalloproteinase-2 in preinvasive and invasive carcinoma of the uterine cervix.

机译：基质金属蛋白酶2在子宫颈浸润前和浸润癌中的表达。

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PURPOSE: To study the immunohistochemical expression of matrix metalloproteinase-2 (MMP-2) in preinvasive and invasive carcinoma of the uterine cervix so as to demonstrate whether the expression of MMP-2 is an early or late event in the process of dedifferentiation and cancer progression. METHODS: A total number of 50 samples of cervical tissue were studied for MMP-2 immunoreactivity. The cases were selected to include ten normal cases used as a control group, 20 CIN cases and 20 cervical carcinoma cases. The CIN group was subdivided into CIN1 (n = 7), CIN2 (n = 6) and CIN3 (n = 7), while the carcinoma group was represented by squamous cell carcinoma (n = 16) and adenocarcinoma (n = 4). RESULTS: MMP-2 expression was totally absent in control cervices and low-grade squamous intraepithelial lesions, while high-grade squamous intraepithelial neoplasia and invasive carcinoma showed up-regulation of MMP-2 expression with no significant difference concerning the type of carcinoma. This overexpression of MMP-2 points to the possibility that it is an early marker of tumor progression in cervical carcinoma. CONCLUSIONS: MMP-2 has a key role in extracellular matrix degradation and invasion in carcinoma of the uterine cervix. Its expression in high-grade squamous intraepithelial lesions may denote a potential risk for invasion and metastasis.
机译：目的：研究基质金属蛋白酶-2（MMP-2）在子宫颈浸润前和浸润癌中的免疫组织化学表达，以证明MMP-2的表达在去分化和癌变过程中是早期还是晚期。进展。方法：对50份宫颈组织样本进行了MMP-2免疫反应性研究。选择的病例包括10例正常病例，20例CIN病例和20例宫颈癌病例。 CIN组分为CIN1（n = 7），CIN2（n = 6）和CIN3（n = 7），而癌组则以鳞状细胞癌（n = 16）和腺癌（n = 4）为代表。结果：在对照宫颈和低度鳞状上皮内病变中完全没有MMP-2表达，而高级别鳞状上皮内瘤变和浸润性癌则显示MMP-2表达上调，而与癌的类型无明显差异。 MMP-2的这种过度表达表明它是宫颈癌中肿瘤进展的早期标志物的可能性。结论：MMP-2在宫颈癌的细胞外基质降解和侵袭中起关键作用。其在高度鳞状上皮内病变中的表达可能表明存在侵袭和转移的潜在风险。

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