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首页> 外文期刊>European journal of gynaecological oncology >Incidence of multiple primary malignancies in women diagnosed with breast cancer.
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Incidence of multiple primary malignancies in women diagnosed with breast cancer.

机译：被诊断患有乳腺癌的女性多发原发性恶性肿瘤的发生率。

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摘要

Using data from the Umbrian Population Cancer Registry (RTUP) we tested the hypothesis of relationships between several subsequent cancer sites in women who had had breast cancer. New patients (7,840) were collected from the RTUP between 01/01/1994 and 31/12/2006; 24 DCO cases were excluded; 332 successive multiple cancers in 320 patients were recorded. Including all second cancers, metachronous contralateral breast cancer, the observed/expected ratio (SIR) was non-significant. Excluding these cases, SIR was significantly lower whether with or without second skin carcinomas. SIR of all second metachronous contralateral cancers, excluding skin carcinomas, was non-significant. Significantly lower risk involved the colorectum, stomach, pancreas and metachronous breast with different histology. A significant excess was found of melanoma and total second breast cancers, including the contralateral. The excessive skin melanoma in breast cancer survivors was attributed to the relationship with BRCA2 and CDKN2A mutation-positive patients. The excess risk due to the CDKN2A mutation should also include pancreatic cancer which, in the present study, presented a significantly lower risk.
机译：使用来自翁布里亚人口癌症注册处（RTUP）的数据，我们检验了患有乳腺癌的女性随后几个癌症部位之间关系的假设。在1994年1月1日至2006年12月31日期间从RTUP收集了新的患者（7,840）;排除了24个DCO案件;记录了320例患者中的332例连续多发癌。包括所有继发性对侧乳腺癌在内的所有第二种癌症，观察/预期比率（SIR）均不显着。排除这些病例，无论是否患有第二次皮肤癌，SIR均显着降低。除皮肤癌外，所有第二次同期对侧癌的SIR均无统计学意义。具有不同组织学特征的结直肠癌，胃癌，胰腺癌和异时性乳腺癌的风险显着降低。发现黑色素瘤和全部第二种乳腺癌（包括对侧）明显过量。乳腺癌幸存者中过多的皮肤黑色素瘤归因于与BRCA2和CDKN2A突变阳性患者的关系。由CDKN2A突变引起的额外风险还应包括胰腺癌，在本研究中，胰腺癌的风险要低得多。

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