Chemotherapy and the future: microdialysis as a local administration technique.

Martins FC; de-Oliveira CF

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Chemotherapy and the future: microdialysis as a local administration technique.

机译：化学疗法和未来：微透析作为一种局部给药技术。

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Chemotherapy has an important role in cancer treatment. Although there have been developments and good results, chemotherapy still has many limitations mainly due to its toxicity and to the resistance mechanisms of tumour cells. Therefore, besides other important improvements in chemotherapy agents and indications, recent researches have focused on the development of locoregional administration techniques, with which therapeutic weapons can reach the tumour with a higher concentration and fewer side-effects. At present, local chemotherapy includes delivery systems or prodrug strategies, arterial infusions, intraperitoneal administration and aerosolised agents. We will describe a new local cancer chemotherapy method, using microdyalisis procedures, which may revolutionise the actual tumour management because of the higher effectiveness and the absence of side-effects. Finally, the applications and limitations of this technique will be considered.

机译：化学疗法在癌症治疗中具有重要作用。尽管已经有了发展和良好的结果，但是化学疗法仍具有许多局限性，这主要是由于其毒性和肿瘤细胞的耐药机制。因此，除了化学治疗药物和适应症的其他重要改进之外，最近的研究集中在局部给药技术的发展上，利用该技术可以使治疗性武器以更高的浓度和更少的副作用到达肿瘤。目前，局部化疗包括递送系统或前药策略，动脉输注，腹膜内给药和气雾剂。我们将描述一种新的局部癌症化疗方法，该方法采用微透析疗法，由于其更高的疗效和无副作用，可能会彻底改变实际的肿瘤治疗方法。最后，将考虑该技术的应用和局限性。

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《European journal of gynaecological oncology》 |2009年第1期|共4页
作者
Martins FC; de-Oliveira CF;
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正文语种 eng
中图分类妇产科学;
关键词
Antineoplastic Agents; Drug Administration Routes; Drug Delivery Systems; 抗肿瘤药; 投药途径; 药物投与系统; 预测; 微透析; 肿瘤;

机译：Antineoplastic Agents;Drug Administration Routes;Drug Delivery Systems;抗肿瘤药;投药途径;药物投与系统;预测;微透析;肿瘤;

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机译：化学疗法和未来：微透析作为一种局部给药技术。
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Chemotherapy and the future: microdialysis as a local administration technique.

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