Repeat chemosensitivity of epithelial ovarian carcinoma in a BRCA1 mutation carrier to paclitaxel/platinum combination chemotherapy.

Melichar B; Fridrichova P; Tomsova M

首页> 外文期刊>European journal of gynaecological oncology >Repeat chemosensitivity of epithelial ovarian carcinoma in a BRCA1 mutation carrier to paclitaxel/platinum combination chemotherapy.

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Repeat chemosensitivity of epithelial ovarian carcinoma in a BRCA1 mutation carrier to paclitaxel/platinum combination chemotherapy.

机译：重复BRCA1突变载体中的上皮性卵巢癌对紫杉醇/铂联合化疗的化学敏感性。

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We present here a case of a BRCA1 mutation carrier with repeat responsiveness of recurrent EOC to paclitaxel/platinum. The patient had complete response to the combination of paclitaxel/platinum in the first line. Subsequent four recurrences also showed a complete response to this combination. The chronic toxicity, including hypersensitivity and nephrotoxicity could be controlled by modifying the regimen. In conclusion, recurrent EOC in BRCA1 mutation carriers may retain sensitivity to paclitaxel/platinum combination chemotherapy, and this combination could be therapy of first choice in this patient population.

机译：我们在这里介绍一例BRCA1突变携带者，复发性EOC对紫杉醇/铂的重复应答。在第一行中，患者对紫杉醇/铂类药物的组合有完全反应。随后的四次复发也显示出对该组合的完全反应。慢性毒性，包括超敏反应和肾毒性可以通过修改方案来控制。总之，BRCA1突变携带者中复发性EOC可能对紫杉醇/铂类联合化疗保持敏感性，这种联合治疗可能是该患者人群的首选治疗方法。

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《European journal of gynaecological oncology》 |2009年第3期|共3页
作者
Melichar B; Fridrichova P; Tomsova M;
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正文语种 eng
中图分类妇产科学;
关键词
Paclitaxel; Platinum; BRCA1 Genes; Mutation; Drug Therapy; Combination;

机译：紫杉醇;铂;BRCA1基因;突变;药物治疗;联合;

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1. Repeat chemosensitivity of epithelial ovarian carcinoma in a BRCA1 mutation carrier to paclitaxel/platinum combination chemotherapy. [J] . Melichar B, Fridrichova P, Tomsova M European journal of gynaecological oncology . 2009,第3期

机译：重复BRCA1突变载体中的上皮性卵巢癌对紫杉醇/铂联合化疗的化学敏感性。
2. Topotecan versus treosulfan, an alkylating agent, in patients with epithelial ovarian cancer and relapse within 12 months following 1st-line platinum/paclitaxel chemotherapy. A prospectively randomized phase III trial by the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group (AGO-OVAR). [J] . Meier W, du Bois A, Reuss A Gynecologic Oncology: An International Journal . 2009,第2期

机译：拓扑替康与烷基化剂海洛因相比，上皮性卵巢癌患者在一线铂/紫杉醇化疗后12个月内复发。一项由Arbeitsgemeinschaft妇科肿瘤卵巢癌研究小组（AGO-OVAR）进行的前瞻性随机III期试验。
3. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. [J] . Swisher EM, Sakai W, Karlan BY, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2008,第8期

机译：具有铂耐药性的BRCA1突变卵巢癌中的继发性BRCA1突变。
4. An Integrated Microfluidic Platform for Detecting BRCA1/BRCA2 Gene Mutation and Risk Assessment of Ovarian Cancer [C] . Yu-Hung Cheng, Chih-Hung Wang, Keng-Fu Hsu, International Conference on Solid-State Sensors, Actuators and Microsystems . 2021

机译：一种用于检测BRCA1 / BRCA2基因突变和卵巢癌风险评估的集成微流体平台
5. Dolo?anje Mutacij v Genih BRCA1/2 Iz citolo?kega Materiala Pri Raku jaj?nikov, Jajcevodov in Primarnem Peritonealnem Seroznem Karcinomu =BRCA1/2 mutation testing from cytological samples in patients with ovarian, tubal and primary peritoneal serous cancer [D] . Gornjec, Andreja. 2020

机译：从自我癌症中确定基因Krca1 / 2中的突变吗？
6. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance [O] . Elizabeth M. Swisher, Wataru Sakai, Beth Y. Karlan, -1

机译：具有铂耐药性的BRCA1突变卵巢癌的继发性BRCA1突变
7. A genomic instability score in discriminating nonequivalent outcomes of BRCA1/2 mutations and in predicting outcomes of ovarian cancer treated with platinum-based chemotherapy. [O] . Shaojun Zhang, Yuan Yuan, Dapeng Hao 2014

机译：鉴别BRCa1 / 2突变的非等效结果和预测用铂类化疗治疗的卵巢癌结果的基因组不稳定性评分。
8. Mechanism of Ovarian Epithelial Tumor Predisposition in Individuals Carrying Germline BRCA1 Mutations [R] . Dubeau, L. 2006

机译：携带种系BRCa1突变的个体卵巢上皮性肿瘤易感性的机制

Repeat chemosensitivity of epithelial ovarian carcinoma in a BRCA1 mutation carrier to paclitaxel/platinum combination chemotherapy.

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