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首页> 外文期刊>European journal of gynaecological oncology >Fractional allelic loss as a potential biomarker of risk prediction in early-stage mucinous ovarian tumors of low malignant potential.
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Fractional allelic loss as a potential biomarker of risk prediction in early-stage mucinous ovarian tumors of low malignant potential.

机译：分数等位基因缺失是低恶性潜能的早期粘液性卵巢肿瘤风险预测的潜在生物标志物。

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Ovarian tumors of low malignant potential (LMP) appear to be intermediate between adenomas and ovarian carcinomas. Such tumors are often associated with a significantly better prognosis than for ovarian carcinomas. However, a subset of LMPs can progress and become lethal even in patients with early-stage disease. In order to seek sensitive diagnostic tools to monitor patients after surgical therapy, we performed a genome-wide scan for LOH in 37 early-stage mucinous LMPs using 91 polymorphic microsatellite markers at an average interval of 50 cM across all of the human chromosomes and 25 LOH markers reported to be associated with ovarian carcinoma. Fractional allelic loss (FAL) values were calculated as (loci scored with LOH)/(total informative loci) for each sample. With respect to tumor recurrence, high FAL values were more frequent in recurrent tumors than in non-recurrent tumors. Using the screening markers, FAL values for recurrent tumors were significantly higher than for non-recurrent tumors (19.8% vs 6.3%, respectively, p < 0.0001). Similar results were obtained using the hotspot markers (22.2% vs 7.1%, respectively, p < 0.0001). A significant correlation between FAL values obtained using screening markers and those based on hotspot markers was observed (R = 0.460, p = 0.003). Our findings suggest that a specific type of genetic instability (i.e., chromosomal instability, CIN) may exist in mucinous LMPs, and that this instability may indicate tumors with an aggressive biological nature. Therefore, FAL values may represent a new biomarker for risk prediction in early-stage mucinous LMP tumors.
机译：低恶性潜能（LMP）的卵巢肿瘤似乎在腺瘤和卵巢癌之间。与卵巢癌相比，这类肿瘤的预后通常要好得多。但是，即使在患有早期疾病的患者中，一部分LMP也会进展并致死。为了寻找敏感的诊断工具来监测手术治疗后的患者，我们使用91个多态性微卫星标记物在所有人类染色体上平均间隔为50 cM和25个平均间隔，对37个早期粘液性LMP中的LOH进行了全基因组扫描据报道LOH标记与卵巢癌有关。计算每个样品的等位基因分数丢失（FAL）值是（用LOH评分的位置）/（信息位点总数）。关于肿瘤复发，复发性肿瘤中的高FAL值比非复发性肿瘤中高。使用筛选标记，复发性肿瘤的FAL值明显高于非复发性肿瘤（分别为19.8％和6.3％，p <0.0001）。使用热点标记获得了相似的结果（分别为22.2％和7.1％，p <0.0001）。观察到使用筛选标记获得的FAL值与基于热点标记获得的FAL值之间存在显着相关性（R = 0.460，p = 0.003）。我们的发现表明，粘液性LMP中可能存在特定类型的遗传不稳定性（即染色体不稳定性，CIN），并且这种不稳定性可能表明肿瘤具有侵略性的生物学性质。因此，FAL值可能代表了早期粘液性LMP肿瘤风险预测的新生物标记。

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