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首页> 外文期刊>European journal of gastroenterology and hepatology >Characteristics and regional variations of patients with Barrett's oesophagus in the UK.
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Characteristics and regional variations of patients with Barrett's oesophagus in the UK.

机译：英国Barrett食管患者的特征和区域差异。

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SUMMARY: OBJECTIVES To establish the patient characteristics and regional variation of Barrett's oesophagus in the UK in a large number (5717) of subjects. Barrett's oesophagus is a precursor lesion of oesophageal adenocarcinoma, the incidence of which is rising more rapidly than any other solid tumour.METHODS Demographic data of 5717 Barrett's oesophagus patients from 27 UK centres, each registering at least 50 patients, with UK National Barrett's Oesophagus Registry, were analysed.RESULTS Centres registering patients were distributed evenly throughout the UK. There was an excess of males, with a male to female ratio of 1.7. Mean age at diagnosis was 62.0 years for males and 67.5 years for females. In Scotland, the mean and peak age at diagnosis for males was lower than for the remainder of the UK. In contrast, there was no regional variation in mean and peak age of diagnosis for females.In 3880 Barrett's oesophagus patients with complete data, adenocarcinoma developed in 136 (3.5%). Adenocarcinoma prevalence was 4.0% in males and 2.5% in females. The male/female ratio of patients with adenocarcinoma was 3.0, twice that of Barrett's oesophagus (1.7). The mean age was 64.7 years for males and 74.0 years for females.CONCLUSIONS These data demonstrate that Barrett's oesophagus occurs with a higher frequency in males, with progression to adenocarcinoma being even more biased towards men in the UK, in contrast to the USA. There are significant regional variations in age of diagnosis of Barrett's oesophagus, especially in younger male patients in Scotland. Studies to identify genetic and environmental determinants of Barrett's oesophagus and cancer risk are needed.
机译：摘要：目的在大量（5717）受试者中确定英国巴雷特食管的患者特征和区域变异。 Barrett食道是食道腺癌的前体病变，其发生率比任何其他实体瘤上升更快。METHODS来自27个英国中心的5717 Barrett食道患者的人口统计数据，每个患者至少注册了50例患者，并获得了英国国家Barrett食道癌注册机构的批准结果登记患者的中心在整个英国平均分布。男性过多，男女之比为1.7。男性的平均诊断年龄为62.0岁，女性为67.5岁。在苏格兰，男性的平均诊断年龄和高峰年龄低于英国其他地区。相比之下，女性的平均诊断年龄和最高年龄没有区域差异。在3880名具有完整数据的巴雷特食管患者中，有136例发生了腺癌（3.5％）。男性的腺癌患病率为4.0％，女性为2.5％。腺癌患者的男女比例为3.0，是Barrett食道的两倍（1.7）。结论男性的平均年龄为64.7岁，女性的平均年龄为74.0岁。结论这些数据表明，与美国相比，巴雷特食管在男性中的发生频率更高，在英国，男性发展为腺癌的倾向甚至更偏向于男性。巴雷特食管的诊断年龄存在明显的地区差异，特别是在苏格兰的年轻男性患者中。需要进行研究以鉴定Barrett食道的遗传和环境决定因素以及癌症风险。

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