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首页> 外文期刊>European journal of gastroenterology and hepatology >A case-control study of childhood environmental risk factors for the development of inflammatory bowel disease.
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A case-control study of childhood environmental risk factors for the development of inflammatory bowel disease.

机译：儿童发炎性肠病发展的环境危险因素的病例对照研究。

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OBJECTIVE : To clarify the relationship between childhood environment and the risk of subsequent development of Crohn's disease or ulcerative colitis. DESIGN AND OUTCOME MEASURES : A case-control study, assessing the risk of inflammatory bowel disease in relation to a series of historical and serological markers of childhood circumstance, analysed using the maximum likelihood form of conditional logistic regression. SETTING : District general hospital (secondary care institution). PARTICIPANTS : Subjects with Crohn's disease (n = 139) or ulcerative colitis (n = 137) aged between 16 and 45 years, each matched for sex and age with an outpatient control. RESULTS : Helicobacter seroprevalence was substantially reduced in Crohn's disease (OR 0.18; 95% CI, 0.06-0.52) but not in ulcerative colitis (OR 0.91; 95% CI, 0.38-2.16). In ulcerative colitis, a strong negative association with childhood appendectomy was confirmed (OR 0.05; 95% CI, 0.01-0.51). Crohn's disease was associated with childhood eczema (OR 2.81; 95% CI, 1.23-6.42) and the frequent use of a swimming pool (OR 2.90; 95% CI 1.21-6.91). There was no association between hepatitis A seroprevalence and either disease. CONCLUSION : The findings are consistent with the hypothesis that improved childhood living conditions are associated with increased risk of Crohn's disease. The study confirms that the negative association between appendectomy and ulcerative colitis relates primarily to events in childhood. Overall, the findings strongly support the assertion that childhood environment is an important determinant of the risk of inflammatory bowel disease in later life, with quite distinct risk factors for ulcerative colitis and Crohn's disease.
机译：目的：澄清儿童环境与克罗恩氏病或溃疡性结肠炎随后发展风险之间的关系。设计和观察指标：一项病例对照研究，评估与儿童期一系列历史和血清学指标有关的炎性肠病风险，并使用条件逻辑回归的最大似然形式进行了分析。地点：地区综合医院（二级护理机构）。参与者：年龄在16至45岁之间的克罗恩病（n = 139）或溃疡性结肠炎（n = 137）的受试者，其性别和年龄均与门诊患者匹配。结果：在克罗恩氏病中，幽门螺杆菌的血清阳性率显着降低（OR 0.18; 95％CI，0.06-0.52），但在溃疡性结肠炎中却没有降低（OR 0.91; 95％CI，0.38-2.16）。在溃疡性结肠炎中，证实与儿童阑尾切除术有很强的负相关性（OR 0.05; 95％CI，0.01-0.51）。克罗恩病与儿童湿疹（OR 2.81; 95％CI，1.23-6.42）和频繁使用游泳池有关（OR 2.90; 95％CI 1.21-6.91）。甲型肝炎血清阳性率与任何一种疾病之间均无关联。结论：这些发现与假想是一致的，即儿童生活条件改善与克罗恩病风险增加有关。该研究证实，阑尾切除术和溃疡性结肠炎之间的负相关性主要与儿童时期的事件有关。总体而言，这些发现强烈支持这样的论断，即儿童期环境是以后生活中炎症性肠病风险的重要决定因素，而溃疡性结肠炎和克罗恩氏病的风险因素却截然不同。

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