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首页> 外文期刊>European journal of gastroenterology and hepatology >Gastric epithelial cell proliferation and ras oncogene p21 expression in first-degree relatives of gastric cancer patients: a case-control study.
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Gastric epithelial cell proliferation and ras oncogene p21 expression in first-degree relatives of gastric cancer patients: a case-control study.

机译：胃癌患者一级亲属中胃上皮细胞增殖和ras癌基因p21表达的病例对照研究。

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OBJECTIVES: Individuals with a family history of gastric cancer have an increased risk of developing such neoplasia. This study aimed to assess epithelial cell proliferation and ras oncogene mutation in such individuals. METHODS: Twenty dyspeptic, first-degree relatives of patients with gastric cancer and 20 matched controls were enrolled. Endoscopy with biopsies was performed in all cases. Gastric specimens were used to look for Helicobacter pylori infection and to assess both epithelial cell proliferation and ras oncogene expression by immunohistochemistry. RESULTS: Cell proliferation values were not significantly different between the patient and control groups (18.1 +/- 7.1 versus 18.9 +/- 7.4; P = 0.7). Overall, ras mutation was detected in five out of 40 cases, and its distribution was similar between patients and controls (20 versus 10%; P = 0.9), as well as between H. pylori-positive and negative patients (22 versus 9%; P = 0.2). Cell proliferation values tended to be higher in cases with ras mutation than in those without (25.2 +/- 9.4 versus 16.8 +/- 5.8; P = 0.08). Cell proliferation values were significantly higher in H. pylori-positive cases compared with uninfected cases, in both patient (24.7 +/- 4.7 versus 12.5 +/- 2.4; P = 0.0003) and control (25.9 +/- 4.8 versus 13.3 +/- 2.8; P = 0.0003) groups. CONCLUSIONS: Both gastric cell proliferation values and ras mutation prevalence did not differ between first-degree relatives of gastric cancer patients and controls. H. pylori infection similarly increased the proliferation index of gastric mucosa in both groups.
机译：目的：具有胃癌家族史的人发生此类肿瘤的风险增加。这项研究旨在评估此类个体的上皮细胞增殖和ras癌基因突变。方法：招募了20例胃癌患者的消化不良一级亲属和20名配对对照。所有病例均进行活检内窥镜检查。胃标本用于寻找幽门螺杆菌感染，并通过免疫组织化学评估上皮细胞增殖和ras癌基因表达。结果：患者和对照组之间的细胞增殖值无显着差异（18.1 +/- 7.1对18.9 +/- 7.4; P = 0.7）。总体而言，在40例患者中有5例检测到ras突变，并且它在患者和对照组之间的分布相似（20对10％; P = 0.9），以及幽门螺杆菌阳性和阴性患者之间（22对9％） ; P = 0.2）。具有ras突变的患者的细胞增殖值往往高于没有ras突变的患者（25.2 +/- 9.4对16.8 +/- 5.8; P = 0.08）。与未感染的病例相比，幽门螺杆菌阳性病例的细胞增殖值明显高于未感染的病例（24.7 +/- 4.7对12.5 +/- 2.4; P = 0.0003）和对照（25.9 +/- 4.8对13.3 + / -2.8; P = 0.0003）组。结论：胃癌患者一级亲属与对照组之间的胃细胞增殖值和ras突变发生率无差异。两组幽门螺杆菌感染同样增加了胃黏膜的增殖指数。

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