Cytokines, for better or worse?

Simpson KJ

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Cytokines, for better or worse?

机译：细胞因子，好还是坏？

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Cytokines play an important role in the pathogenesis of many diseases including liver failure. Both newly described and 'classic' pro-inflammatory cytokines, such as tumour necrosis factor-alpha, have been implicated in both hepatic injury and liver regeneration. In addition, increased circulating concentrations of these cytokines suggest they may have a hormone-like endocrine effect on tissues distant to their production, leading to the hypotension, lung injury and cerebral oedema that occur in such patients. Increased understanding of the cytokine networks involved in acute liver failure may lead to the development of novel therapies, which may reduce the requirement for liver transplantation in this condition.

机译：细胞因子在包括肝衰竭在内的许多疾病的发病机理中起着重要作用。新近描述的和“经典的”促炎细胞因子，例如肿瘤坏死因子-α，都与肝损伤和肝再生有关。另外，这些细胞因子的循环浓度增加表明它们可能对远离其产生的组织具有类激素的内分泌作用，导致此类患者发生低血压，肺损伤和脑水肿。对与急性肝衰竭有关的细胞因子网络的了解的增加可能会导致新疗法的发展，这可能会减少这种情况下肝移植的需求。

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《European journal of gastroenterology and hepatology》 |1999年第9期|共10页
作者
Simpson KJ;
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正文语种 eng
中图分类消化系及腹部疾病;
关键词
Cytokines; Liver; Liver Failure; Acute; Growth Substances; Interleukins; 细胞活素类; 肝; 肝功能衰竭; 急性;

机译：Cytokines;Liver;Liver Failure;Acute;Growth Substances;Interleukins;细胞活素类;肝;肝功能衰竭;急性;

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机译：长期非编码RNA UCA1与急性缺血性卒中患者的疾病严重程度，Th17细胞比例，炎症性细胞因子和更差的预后相关
2. Worse and Worse and Worse: Essential Tremor Patients’ Longitudinal Perspectives on Their Condition [J] . Jesús Gutierrez, Jemin Park, Olufunmilayo Badejo, Frontiers in Neurology . 2016,第2016期

机译：越来越糟：基本震颤患者对病情的纵向看法
3. Atopic Dermatitis and Cytokines: Recent Patents in Immunoregulatory and Therapeutic Implications of Cytokines in Atopic Dermatitis - Part I: Cytokines in Atopic Dermatitis [J] . JaeHo. Lee, Geunwoong Noh, Soojin Lee, Recent Patents on Inflammation & Allergy Drug Discovery . 2012,第3期

机译：特应性皮炎和细胞因子：特应性皮炎中细胞因子的免疫调节和治疗意义的最新专利-第一部分：特应性皮炎中的细胞因子
4. Use of the Erenna? Immunoassay Platform to Detect Pro-Inflammatory Cytokines in an In Vitro Cytokine Release Assay [C] . Lynn Zieske, S. Teixeira, S. Salgado-Pires, Molecular Medicine TRI-CON. . 2014

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5. Diversity of Cytokine Expression Patterns in the Th1-Dominated Human Anti-Influenza CD4 T Cell Response Is Due To Both Variable Expression of Cytokines by Committed Th1 Cells, and a Minor Population of Uncommitted IL-2+IFNγ- Thpp Cells [D] . Deng, Nan 2014

机译：Th1为主的人类抗流感CD4 T细胞反应中细胞因子表达模式的多样性是由于既定的Th1细胞可变表达细胞因子，以及少数未定型的IL-2 +IFNγ-Thpp细胞引起的。
6. Long non‐coding RNA UCA1 correlates with elevated disease severity Th17 cell proportion inflammatory cytokines and worse prognosis in acute ischemic stroke patients [O] . Bin Ren, Zhiyuan Song, Laizhao Chen, 2021

机译：长期非编码RNA UCA1与急性缺血性卒中患者的疾病严重程度Th17细胞比例炎症细胞因子和更差的预后相关
7. Worse and Worse and Worse: Essential Tremor Patients’ Longitudinal Perspectives on Their Condition [O] . Jesús Gutierrez, Jemin Park, Olufunmilayo Badejo, 2016

机译：更糟，更糟，更糟：基本震颤患者的纵向视角

Cytokines, for better or worse?

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