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首页> 外文期刊>European journal of gastroenterology and hepatology >Diverticulosis and colorectal polyps at younger age: a possible link?
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Diverticulosis and colorectal polyps at younger age: a possible link?

机译：年轻的憩室病和大肠息肉：可能的联系吗？

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OBJECTIVE: An association between diverticulosis and colorectal neoplasms may have implications for colonoscopic prevention of colorectal cancer. We aimed to examine the association between diverticulosis and colorectal polyps with special attention to the age at diagnosis, the anatomical location, and the histological subtype of colorectal polyps. METHODS: We included all consecutive patients referred for routine colonoscopy between February 2008 and February 2009. We recorded the presence of diverticulosis (defined as at least two diverticula) and colorectal polyps (adenomas and serrated polyps). RESULTS: We included 2310 patients (46.1% men, mean age 58.4 years), of which 37.0% had diverticulosis and 34.2% had one or more colorectal polyps. Multiple logistic regression analysis, including age, sex, and interaction terms with diverticulosis, showed that the association between diverticulosis and colorectal polyps was significantly influenced by age (P=0.009). In patients aged below 60 years, prevalence of colorectal polyps was significantly higher in those with diverticulosis compared with those without diverticulosis: 39.1% (79 of 202 patients) versus 19.6% (176 of 898 patients), adjusted odds ratio (OR) 1.87, 95% confidence interval (CI) 1.26-2.78, and P=0.002. This association was found for both proximal and distal polyps and for all histological subtypes, namely adenomas (adjusted OR 1.60, 95%CI 1.02-2.49, P=0.04), serrated polyps (adjusted OR 1.73, 95% CI 1.03-2.91, and P=0.04), and advanced neoplasms (adjusted OR 2.32, 95%CI 1.31-4.12, P=0.004). CONCLUSION: Presence of diverticulosis in patients aged below 60 years may be considered a 'red flag' for synchronous adenomas, serrated polyps, and advanced neoplasms. Diverticulosis may represent an indication for earlier initiation of colorectal cancer prevention programs.
机译：目的：憩室病与大肠肿瘤之间的关联可能对结肠镜检查预防大肠癌具有重要意义。我们旨在检查憩室病和大肠息肉之间的关系，并特别注意诊断年龄，大肠息肉的解剖位置和组织学亚型。方法：我们纳入了2008年2月至2009年2月之间接受常规结肠镜检查的所有连续患者。我们记录了憩室病（定义为至少两个憩​​室）和结直肠息肉（腺瘤和锯齿状息肉）的存在。结果：我们纳入了2310例患者（男性46.1％，平均年龄58.4岁），其中37.0％患有憩室病，34.2％患有一个或多个大肠息肉。多元逻辑回归分析，包括年龄，性别以及与憩室病的相互作用条件，表明憩室病与结直肠息肉之间的关联受到年龄的显着影响（P = 0.009）。在60岁以下的患者中，憩室病患者的结直肠息肉患病率显着高于无憩室病的患者：39.1％（202例患者中的79例）对19.6％（898例患者中的176例），调整后的优势比（OR）1.87， 95％置信区间（CI）为1.26-2.78，P = 0.002。对于近端和远端息肉以及所有组织学亚型，即腺瘤（调整后的OR 1.60，95％CI 1.02-2.49，P = 0.04），锯齿状息肉（调整后的OR 1.73，95％CI 1.03-2.91，和P = 0.04）和晚期肿瘤（校正OR 2.32，95％CI 1.31-4.12，P = 0.004）。结论：60岁以下患者憩室病的存在可能被认为是同步腺瘤，锯齿状息肉和晚期肿瘤的“危险信号”。憩室病可能是大肠癌预防计划提早启动的迹象。

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