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首页> 外文期刊>European journal of gastroenterology and hepatology >Predictive factors of years of potential life lost by colorectal cancer.
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Predictive factors of years of potential life lost by colorectal cancer.

机译：结直肠癌丧失多年潜在生命的预测因素。

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OBJECTIVE: To evaluate the impact of colorectal cancer (CRC) by estimating the years of potential life lost (YPLL) by this neoplasm in a cohort of patients, as well as to define the predictive factors of YPLL. METHODS: A descriptive cross-sectional study of 980 consecutive patients diagnosed and treated because of CRC in our institution between 1985 and 2002 was carried out. Demographic, clinical, pathological, surgical, hospital stay, complications, and mortality variables were recorded. The primary endpoint of this study was to calculate individual YPLL. Univariate analysis was performed to compare each independent variable with the variable YPLL. All clinically relevant variables significantly associated with YPLL were included in an ordinal regression model to identify independent factors prognostic of YPLL. RESULTS: The final study sample was 794 patients, 413 (52%) men and 381 (48%) women, mean age 65.3 years [confidence interval (CI) 95%: 64.4-66.2 years; SD: 12.8]. The mean global YPLL for the 351 patients who died of CRC was 15.2 years (SD: 10.7; CI 95%: 14.1-16.3). Lower age [odds ratio (OR)=0.98; CI 95%: 0.97-0.98], male sex (OR=1.19; CI 95%: 1.00-1.43), lower tumor, nodes, metastasis (TNM) stage (OR=0.29; CI 95%: 0.24-0.35), and rectum localization of the tumor (OR=1.37; CI 95%: 1.14-1.64) were independent prognostic factors for YPLL. CONCLUSION: In our community, the mean number of YPLL by CRC exceeds 15 years. Lower age, male sex, higher TNM stage, and rectum localization are negative predictors of YPLL.
机译：目的：通过评估这种肿瘤在一组患者中的潜在寿命损失（YPLL）年限来评估结直肠癌（CRC）的影响，并确定YPLL的预测因素。方法：进行描述性横断面研究，研究对象为1985年至2002年间980例因CRC诊断和治疗的连续患者。记录人口统计学，临床，病理，手术，住院时间，并发症和死亡率变量。这项研究的主要目的是计算单个YPLL。进行单变量分析以将每个自变量与变量YPLL进行比较。与YPLL显着相关的所有临床相关变量均包含在序数回归模型中，以鉴定对YPLL预后的独立因素。结果：最终研究样本为794例患者，其中413例（52％）男性和381例（48％）女性，平均年龄65.3岁[置信区间（CI）95％：64.4-66.2岁;平均病程为65岁。 SD：12.8]。 351例死于CRC的患者的平均全球YPLL为15.2年（SD：10.7; CI 95％：14.1-16.3）。较低年龄[比值比（OR）= 0.98; CI 95％：0.97-0.98]，男性（OR = 1.19; CI 95％：1.00-1.43），下肿瘤，淋巴结转移（TNM）阶段（OR = 0.29; CI 95％：0.24-0.35）和肿瘤的直肠定位（OR = 1.37; CI 95％：1.14-1.64）是YPLL的独立预后因素。结论：在我们社区中，CRC导致的YPLL平均数超过15年。较低的年龄，男性，较高的TNM分期和直肠定位是YPLL的阴性指标。

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