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首页> 外文期刊>European journal of gynaecological oncology >Ovarian fibrosarcoma: case report and latest trends in diagnostic and therapeutic management
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Ovarian fibrosarcoma: case report and latest trends in diagnostic and therapeutic management

机译：卵巢纤维肉瘤：病例报告和诊断和治疗管理的最新趋势

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The authors describe a rare case of primary ovarian fibrosarcoma and the latest trends in diagnosis and therapy. The rarity of this disease and the scarce number of reported cases pose serious problems in differentiating it from other fibrous forms. A 58-year-old woman presented intermittent pelvic pain and a demarcated, mobile, and solid lump in the right adnexa. Diagnostic imaging revealed a solid-cystic inhomogeneous mass occupying the right adnexa and the CA125 level was elevated. The patient underwent total hysterectomy with bilateral salpingo-oophorectomy and infracolic omentectomy. Histological findings with immunomarkers led to the final diagnosis of low-grade malignant mesenchymal neoplasm derived from the ovarian stroma compatible with fibrosarcoma. Twenty-four months follow-up showed no recurrence of disease. Ovarian fibrosarcoma is very uncommon neoplasm with a poor prognosis. Despite the efforts of several authors in reporting morphological, histological, and immunohistochemical features of this neoplasm, nowadays, the diagnosis, treatment, and prognosis are unresolved issues. The present case highlights the important role of immunohistochemistry to define histological type and differential diagnosis. As demonstrated by the authors' experience, they believe that surgery is curative in the early stages with low immunohistochemical positivity for ki67 and that chemotherapy should be reserved in advanced stages with regimens in use for the treatment of sarcomas.
机译：作者描述了罕见的原发性卵巢纤维肉瘤病例以及诊断和治疗的最新趋势。这种疾病的稀有性和报告病例的数量稀少，在将其与其他纤维形式区分开来方面造成了严重的问题。一名58岁的女性出现间歇性骨盆疼痛，右附件有分界的，活动的和坚实的肿块。诊断显像显示占右附件的固体囊性不均匀肿块，CA125水平升高。该患者接受了全子宫切除术，双侧输卵管输卵管切除术和腹膜下网膜切除术。免疫标记物的组织学发现可最终诊断出源自与纤维肉瘤相容的卵巢基质的低度恶性间质肿瘤。二十四个月的随访未发现疾病复发。卵巢纤维肉瘤是非常罕见的肿瘤，预后较差。尽管有几位作者在报告这种肿瘤的形态，组织学和免疫组织化学特征方面做出了努力，但如今，诊断，治疗和预后仍未解决。本病例突出了免疫组织化学在定义组织学类型和鉴别诊断中的重要作用。正如作者的经验所表明的那样，他们认为手术可早期治愈，对ki67的免疫组织化学阳性率较低，并且化疗应保留在晚期，并应采用治疗肉瘤的方案。

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