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首页> 外文期刊>European Journal of Haematology >Increased expression of TF on monocytes, but decreased numbers of TF bearing microparticles in blood from patients with acute myocardial infarction.
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Increased expression of TF on monocytes, but decreased numbers of TF bearing microparticles in blood from patients with acute myocardial infarction.

机译：急性心肌梗死患者血液中TF的表达增加，但血液中带有TF的微粒数量减少。

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摘要

Occlusive thrombus formation after disruption of an atherosclerotic plaque is thought to be the cause of acute myocardial infarction (AMI). Tissue factor (TF) is regarded as a key regulator of this process. We read with great interest the paper by Maly et al. (2), which measured TF activity and microparticle count in platelet free plasma. The authors reported that TF activity and microparticle counts were decreased in platelet free plasma of patients with unstable angina and patients with AMI compared to healthy controls and a group of patients with stable angina pectoris. To the best of our knowledge, this was the first study that reported a decrease of circulating procoagulant microparticles in patients with an arterial thrombosis. Yet, the results of this study are in line with the current concept of cell-based coagulation. In this concept, TF bearing micro-particles are recruited from circulating blood by binding to a surface of activated cells (platelets, monocytes, endothelial cells), where the delivered TF together with the activated cell surfaces stimulates thrombin generation and further (occlusive) thrombus growth. Maly et al. already very properly observed that their results should be interpreted with caution, because they were the first to measure TF activity in patients with acute coronary syndrome and the numbers of patients and controls were limited. However, recent findings in our laboratory strongly support their results.
机译：动脉粥样硬化斑块破裂后闭塞性血栓形成被认为是急性心肌梗塞（AMI）的原因。组织因子（TF）被认为是该过程的关键调节因子。我们非常感兴趣地阅读了Maly等人的论文。 （2）测量了无血小板血浆中的TF活性和微粒数。作者报告说，与健康对照组和一组稳定型心绞痛患者相比，不稳定型心绞痛患者和AMI患者的无血小板血浆中TF活性和微粒计数降低。据我们所知，这是第一项报道动脉血栓形成患者循环血凝微粒减少的研究。然而，这项研究的结果与当前基于细胞的凝结概念相一致。在这个概念中，通过结合到活化细胞（血小板，单核细胞，内皮细胞）的表面，从循环血液中募集带有TF的微粒，其中所输送的TF与活化的细胞表面一起刺激凝血酶的产生并进一步（闭塞）血栓增长。 Maly等。已经非常恰当地观察到，应谨慎地解释其结果，因为它们是最早测​​量急性冠状动脉综合征患者的TF活性的方法，患者和对照组的人数有限。但是，我们实验室的最新发现强烈支持了他们的结果。

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