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首页> 外文期刊>European journal of gastroenterology and hepatology >Qualitative and quantitative clinical evaluation of the laser-assisted ratio analyser for detection of Helicobacter pylori infection by (13)C-urea breath tests.
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Qualitative and quantitative clinical evaluation of the laser-assisted ratio analyser for detection of Helicobacter pylori infection by (13)C-urea breath tests.

机译：激光辅助比率分析仪通过（13）C-尿素呼气试验检测幽门螺杆菌感染的定性和定量临床评估。

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OBJECTIVES: Currently, the (13)C-urea breath test is the reference method for non-invasive diagnosis of Helicobacter pylori infection and therapy control. Therefore, new technologies have been developed to measure the ratio of (13)CO(2)/(12)CO(2) in breath. The laser-assisted ratio analyser (LARA) device is based on optogalvanic effects of the stimulated CO(2) molecules. DESIGN: In this study, the LARA system is prospectively compared to conventional isotope ratio mass spectrometry (IRMS) analysis of (13)C-urea breath tests. METHODS: The (13)C-urea breath test was used to screen 103 patients for H. pylori infection. Breath samples were analysed by LARA and IRMS techniques. RESULTS: Seven breath tests could not be analysed by the LARA system, one by IRMS. Out of the remaining 95 breath tests, 13 were positive for H. pylori infection (13.7%). In reference to IRMS analysis (with a cut-off of > 5 delta per thousand at 30 min), LARA produced one false positive and one false negative breath test result giving a sensitivity of 92.3% and a specificity of 98.8%. The mean difference in delta over baseline values between IRMS and LARA measurements was 2.02 delta per thousand +/- 5.48 delta per thousand. CONCLUSION: LARA allows the reliable qualitative evaluation of 13C-urea breath tests, but the quantitative results differ from IRMS findings.
机译：目的：目前，（13）C-尿素呼气试验是非侵入性诊断幽门螺杆菌感染和治疗控制的参考方法。因此，已开发出新技术来测量呼吸中（13）CO（2）/（12）CO（2）的比率。激光辅助比率分析仪（LARA）设备基于受刺激的CO（2）分子的光电效应。设计：在这项研究中，将LARA系统与（13）C-尿素呼气试验的常规同位素比质谱（IRMS）分析进行了比较。方法：采用（13）C-尿呼气试验筛查103例幽门螺杆菌感染患者。呼吸样品通过LARA和IRMS技术进行分析。结果：LARA系统无法分析七个呼吸测试，IRMS无法分析一个。在其余的95次呼气试验中，有13例幽门螺杆菌感染呈阳性（13.7％）。参照IRMS分析（在30分钟时截止>千分之五），LARA产生了1次假阳性和1次假阴性呼气测试结果，灵敏度为92.3％，特异性为98.8％。 IRMS和LARA测量值之间的相对于基线值的平均差是2.02 Delta /千+/- 5.48 Delta /千。结论：LARA可以对13C-尿素呼气试验进行可靠的定性评估，但定量结果与IRMS的发现有所不同。

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