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首页> 外文期刊>European journal of gynaecological oncology >Serum adiponectin in relation to endometrial cancer and endometrial hyperplasia with atypia in obese women.
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Serum adiponectin in relation to endometrial cancer and endometrial hyperplasia with atypia in obese women.

机译：肥胖妇女血清脂联素与子宫内膜癌和子宫内膜增生伴异型症的关系。

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OBJECTIVES: The aim of this work was to compare concentrations of adiponectin in the serum of obese women with endometrial cancer, endometrial hyperplasia with atypia, and normal endometrium. METHODS: We enrolled 105 obese women treated at the Department of Gynecological Surgery and Oncology of Adults and Adolescents. The patients were allocated to groups depending on the histological diagnosis (R - endometrial cancer, P - polyps, K - normal endometrium). We subdivided group R depending on the stage and grade of cancer. RESULTS: Significantly lower concentrations of adiponectin were found in patients with endometrial cancer (mean 15.28 microg/ml) as compared with polyps (29.94 microg/ml, p < 0.001) or normal endometrium (22.7 microg/ml, p < 0.05). Stage of cancer had no significant effect on the adiponectin level. When cancer grade was compared, lower levels of adiponectin were observed in patients with G3 (12.86 microg/ml) than G1 (19.04 microg/ml, p < 0.05). CONCLUSION: Reduced levels of adiponectin may represent an independent risk factor for endometrial cancer.
机译：目的：本研究的目的是比较肥胖妇女子宫内膜癌，非典型性子宫内膜增生和正常子宫内膜患者血清脂联素的浓度。方法：我们招募了105名在成人和青少年妇科外科和肿瘤科治疗的肥胖妇女。根据组织学诊断（R-子宫内膜癌，P-息肉，K-正常子宫内膜）将患者分为几组。我们根据癌症的阶段和等级将R组细分。结果：与息肉（29.94 microg / ml，p <0.001）或正常子宫内膜（22.7 microg / ml，p <0.05）相比，子宫内膜癌患者的脂联素浓度显着降低（平均15.28 microg / ml）。癌症分期对脂联素水平无明显影响。比较癌症等级时，G3（12.86 microg / ml）患者的脂联素水平低于G1（19.04 microg / ml，p <0.05）。结论：脂联素水平降低可能是子宫内膜癌的独立危险因素。

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