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首页> 外文期刊>European journal of gynaecological oncology >Decreased microRNA-206 and its function in cervical cancer
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Decreased microRNA-206 and its function in cervical cancer

机译：microRNA-206的表达下降及其在宫颈癌中的作用

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Objective: MicroRNA-206 plays important roles in tumorigenesis and tumor progression of various human malignancies. However, its involvement in cervical cancer has remained unclear. Objective: The aim of this study was to examine the expression patterns and clinical implications of miR-206 in cervical cancer. Materials and Methods: Quantitative RT-PCR was performed to evaluate the expression levels of miR-206 in cervical cancer cell lines and primary tumor tissues. The clinicopathologic significance and the prognostic value of miR-206 expression were further determined. Finally, the effects of miR-206 on HeLa cell proliferation, apoptosis, invasion, and migration were investigated. Results: MiR-206 expression was significantly downregulated in cervical cancer samples when compared with normal adjacent tissues. Low level of miR-206 was associated with advanced FIGO stage (p < 0.001), positive lymph node metastasis (p < 0.001), poor differentiation (p = 0.016), and human papillomavirus infection (p = 0.007). Multivariate Cox regression analysis revealed that decreased miR-206 expression was an independent unfavorable prognostic factor for overall survival. In addition, transfection of miR-206 mimics in HeLa cells was able to reduce cell proliferation, promote cell apoptosis, and inhibit cell invasion and migration. Conclusions: miR-206 may act not only as a novel diagnostic and prognostic marker, but also as a potential target for molecular therapy of cervical cancer.
机译：目的：MicroRNA-206在各种人类恶性肿瘤的发生和发展中起着重要作用。但是，其与宫颈癌的关系仍不清楚。目的：本研究旨在检查miR-206在宫颈癌中的表达模式及其临床意义。材料与方法：进行定量RT-PCR评估miR-206在宫颈癌细胞和原发性肿瘤组织中的表达水平。进一步确定了miR-206表达的临床病理学意义和预后价值。最后，研究了miR-206对HeLa细胞增殖，凋亡，侵袭和迁移的影响。结果：与正常邻近组织相比，宫颈癌样品中的MiR-206表达显着下调。低水平的miR-206与FIGO晚期（p <0.001），淋巴结转移阳性（p <0.001），分化差（p = 0.016）和人乳头瘤病毒感染（p = 0.007）有关。多变量Cox回归分析显示，miR-206表达降低是整体生存的独立不利预后因素。另外，在HeLa细胞中转染miR-206模拟物能够减少细胞增殖，促进细胞凋亡并抑制细胞入侵和迁移。结论：miR-206不仅可以作为一种新型的诊断和预后标志物，而且还可以作为宫颈癌分子治疗的潜在靶标。

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