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首页> 外文期刊>European Journal of Radiology >MR-perfusion (MRP) and diffusion-weighted imaging (DWI) in prostate cancer: quantitative and model-based gadobenate dimeglumine MRP parameters in detection of prostate cancer.
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MR-perfusion (MRP) and diffusion-weighted imaging (DWI) in prostate cancer: quantitative and model-based gadobenate dimeglumine MRP parameters in detection of prostate cancer.

机译：前列腺癌的MR灌注（MRP）和扩散加权成像（DWI）：定量和基于模型的gadobenate dimeglumine MRP参数在前列腺癌的检测中。

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BACKGROUND: Various MR methods, including MR-spectroscopy (MRS), dynamic, contrast-enhanced MRI (DCE-MRI), and diffusion-weighted imaging (DWI) have been applied to improve test quality of standard MRI of the prostate. PURPOSE: To determine if quantitative, model-based MR-perfusion (MRP) with gadobenate dimeglumine (Gd-BOPTA) discriminates between prostate cancer, benign tissue, and transitional zone (TZ) tissue. MATERIAL AND METHODS: 27 patients (age, 65+/-4 years; PSA 11.0+/-6.1 ng/ml) with clinical suspicion of prostate cancer underwent standard MRI, 3D MR-spectroscopy (MRS), and MRP with Gd-BOPTA. Based on results of combined MRI/MRS and subsequent guided prostate biopsy alone (17/27), biopsy and radical prostatectomy (9/27), or sufficient negative follow-up (7/27), maps of model-free, deconvolution-based mean transit time (dMTT) were generated for 29 benign regions (bROIs), 14 cancer regions (cROIs), and 18 regions of transitional zone (tzROIs). Applying a 2-compartment exchange model, quantitative perfusion analysis was performed including as parameters: plasma flow (PF), plasma volume (PV), plasma mean transit time (PMTT), extraction flow (EFL), extraction fraction (EFR), interstitial volume (IV) and interstitial mean transit time (IMTT). Two-sided T-tests (significance level p<0.05) discriminated bROIs vs. cROIs and cROIs vs. tzROIs, respectively. RESULTS: PMTT discriminated best between bROIs (11.8+/-3.0 s) and cROIs (24.3+/-9.6 s) (p<0.0001), while PF, PV, PS, EFR, IV, IMTT also differed significantly (p 0.00002-0.0136). Discrimination between cROIs and tzROIs was insignificant for all parameters except PV (14.3+/-2.5 ml vs. 17.6+/-2.6 ml, p<0.05). CONCLUSIONS: Besides MRI, MRS and DWI quantitative, 2-compartment MRP with Gd-BOPTA discriminates between prostate cancer and benign tissue with several parameters. However, distinction of prostate cancer and TZ does not appear to be reliable.
机译：背景：各种MR方法，包括MR光谱法（MRS），动态，对比增强MRI（DCE-MRI）和扩散加权成像（DWI），已被用于改善前列腺标准MRI的测试质量。目的：确定基于定量的基于模型的MR灌注（MRP）与g酸二聚丁二胺（Gd-BOPTA）是否能区分前列腺癌，良性组织和过渡区（TZ）组织。材料和方法：27例临床怀疑前列腺癌的患者（年龄65岁至4岁; PSA 11.0 +/- 6.1 ng / ml）接受了标准MRI，3D MR光谱法（MRS）和GRP-BOPTA的MRP检查。根据MRI / MRS联合检查结果以及随后单独进行的引导前列腺活检（17/27），活检和前列腺癌根治术（9/27）或足够的阴性随访（7/27），得出无模型，去卷积，基于29个良性区域（bROIs），14个癌症区域（cROIs）和18个过渡带区域（tzROIs）的平均转运时间（dMTT）。应用2室交换模型，进行定量灌注分析，包括以下参数：血浆流量（PF），血浆体积（PV），血浆平均通过时间（PMTT），提取流量（EFL），提取分数（EFR），间隙体积（IV）和间隙平均通过时间（IMTT）。双向T检验（显着性水平p <0.05）分别区分了bROIs对cROIs和cROIs对tzROIs。结果：PMTT在bROIs（11.8 +/- 3.0 s）和cROIs（24.3 +/- 9.6 s）之间最佳地区分（p <0.0001），而PF，PV，PS，EFR，IV，IMTT也有显着差异（p 0.00002- 0.0136）。对于除PV以外的所有参数，cROIs和tzROIs之间的差异均不显着（14.3 +/- 2.5 ml与17.6 +/- 2.6 ml，p <0.05）。结论：除了MRI，MRS和DWI定量分析外，带有Gd-BOPTA的2隔室MRP还可以通过几个参数来区分前列腺癌和良性组织。但是，区分前列腺癌和TZ似乎并不可靠。

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