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首页> 外文期刊>European Journal of Histochemistry >Histochemical properties of sialic acids and antimicrobial substances in canine anal glands
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Histochemical properties of sialic acids and antimicrobial substances in canine anal glands

机译：唾液酸和抗菌物质在犬肛门腺中的组织化学特性

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摘要

The functional properties of sialic acids appear to be manifold. Additionally, antimicrobial substances serve as a non-specific defense against microorganisms. In this study, therefore, the localization of sialic acids and antimicrobial substances in the anal glands of dog was studied by sialoglycocònjugate histochemistry and immunohistochemistry. The secretory epithelium, luminal secretions and excretory ducts exhibited high levels of sialoglycocon-jugates that terminated in Siaa2-6Gal/GalNAc or Siaa2-3GaIl-4GlcNAc. Additionally, O-acety-lated sialic acids were detectable in these glandular structures. Antimicrobial substances, such as lysozyme, immunoglobulin A (IgA), lactoferrin and the peptide group of (3-defensins, were also demonstrated as products of the anal glands. The results obtained are discussed with regard to the functional significance of the anal glands. These secretory products may create a defensive barrier against microbial invasion at the anal mucosa.
机译：唾液酸的功能特性似乎是多方面的。另外，抗微生物物质用作针对微生物的非特异性防御​​。因此，在这项研究中，通过唾液酸糖结合组织化学和免疫组织化学研究了唾液酸和抗菌物质在狗肛门腺中的定位。分泌上皮，管腔分泌物和排泄管表现出高水平的唾液糖共轭物，其终止于Siaa2-6Gal / GalNAc或Siaa2-3Gal1-4GlcNAc。另外，在这些腺结构中可检测到O-乙酸化的唾液酸。还证明了诸如溶菌酶，免疫球蛋白A（IgA），乳铁蛋白和（3-防御素）肽组等抗菌物质是肛门腺的产物，并讨论了有关肛门腺功能性意义的结果。这些分泌产物可能对肛门粘膜产生防御微生物入侵的防御屏障。

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