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首页> 外文期刊>European heart journal cardiovascular Imaging >Integrated backscatter as a fibrosis marker in the metabolic syndrome: Association with biochemical evidence of fibrosis and left ventricular dysfunction
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Integrated backscatter as a fibrosis marker in the metabolic syndrome: Association with biochemical evidence of fibrosis and left ventricular dysfunction

机译：整合后向散射作为代谢综合征中纤维化的标志物：与纤维化和左心功能不全的生化证据相关

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Aims: Myocardial fibrosis is an important contributor to heterogeneity of left ventricular (LV) dysfunction in the metabolic syndrome (MS). Comparison of strain with calibrated integrated backscatter (cIB) and serological fibrosis markers could provide a means to understand the association of cardiac function with markers of fibrosis. Methods and results: We studied 172 patients with MS (age 50 ± 13 years) and 61 healthy controls in a prospective, cross-sectional study. Echocardiographic evaluation included myocardial velocities and deformation, and calibrated cIB. Procollagen type III amino-terminal propeptide (PIIINP) and procollagen type I carboxy-terminal propeptide (PICP) were measured from serum. MS patients demonstrated LV systolic and diastolic function, and myocardial echodensity disturbances, as well as elevated serum PIIINP and PICP levels. For most functional variables, calibrated cIB in the basal septum was the strongest determinant of impaired LV performance, independent of higher procollagen levels, LV mass index, age, body mass index, creatinine level, and C-reactive protein. Patients with increased abdominal fat deposit (assessed by the waist-to-hip ratio) presented higher levels of procollagen peptides and septal calibrated cIB, and with more profound LV dysfunction as indicated by lower myocardial deformation and early diastolic velocity, and higher E/e′. Conclusion: Myocardial echodensity is a stronger correlate of LV systolic and diastolic dysfunction in MS, than circulating procollagen peptides. Both fibrosis and LV function abnormalities are increased at a higher waist-to-hip ratio, which might provide a rationale for the implementation of intensified therapy in this subset of patients. Published on behalf of the European Society of Cardiology. All rights reserved.
机译：目的：心肌纤维化是代谢综合征（MS）中左心室（LV）功能障碍异质性的重要原因。校准后的背向散射积分（cIB）与血清学纤维化标记物的比较可以为了解心脏功能与纤维化标记物之间的联系提供一种手段。方法和结果：我们在一项前瞻性横断面研究中研究了172例MS患者（年龄50±13岁）和61例健康对照者。超声心动图评估包括心肌速度和变形，以及校准的cIB。从血清中测量前胶原III型氨基末端前肽（PIIINP）和前胶原I型羧基末端前肽（PICP）。 MS患者表现出左室收缩和舒张功能，心肌回声密度障碍以及血清PIIINP和PICP水平升高。对于大多数功能变量，基底隔膜中校准的cIB是左室功能受损的最强决定因素，而与较高的前胶原水平，左室质量指数，年龄，体重指数，肌酐水平和C反应蛋白无关。腹部脂肪沉积增加（通过腰臀比评估）的患者表现出较高的前胶原肽水平和隔垫校准的cIB水平，并表现为更严重的LV功能障碍，如较低的心肌变形和早期舒张速度以及较高的E / e '。结论：与循环前胶原肽相比，心肌的回声密度与MS的LV收缩功能和舒张功能障碍之间存在更强的相关性。较高的腰臀比率会增加纤维化和左室功能异常，这可能为在该患者亚群中实施强化治疗提供了依据。代表欧洲心脏病学会出版。版权所有。

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