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首页> 外文期刊>European heart journal cardiovascular Imaging >Clinical impact of 18F-FDG-PET/CT in the extra cardiac work-up of patients with infective endocarditis
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Clinical impact of 18F-FDG-PET/CT in the extra cardiac work-up of patients with infective endocarditis

机译：18F-FDG-PET / CT对感染性心内膜炎患者额外心脏检查的临床影响

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Objective: The purpose of this studywas to assess the clinical importance of 18F-FDG-PET/CT used in the extra cardiac work-up of patients with infective endocarditis (IE). Background: IE is a serious condition with a significant mortality. Besides the degree of valvular involvement, the prognosis relies crucially on the presence of systemic infectious embolism. Methods: Seventy-two patients (71% males and mean age 63±17 years) with IEwere evaluated with 18F-FDG-PET/CT in addition to standard work-up including patient history, physical examination, conventional imaging modalities, and weekly interdisciplinary conferences. Whenprevious unknown lesions detected by 18F-FDG-PET/CT were confirmed by succeeding examinations, they were considered true positive new findings and were further assessed for their clinical importance. Number needed to investigate was calculated as the number of patients who needed to undergo 18F-FDG- PET/CT to find at least one clinical important true positive new finding, not identified by standard work-up prior to 18F-FDG-PET/CT. Results: 18F-FDG-PET/CT detected 114 lesions and 64 were true positive, of which 25 were new findings and detected in 17 patients. In 11 patients, the lesions were considered to have a clinical importance; osteomyelitis (n = 7), iliopsoas abscess (n = 1), gastrointestinal lesions (n = 2), and vascular prosthetic graft (n = 1). Number needed to investigate was 7 (11 of 72 patients). Conclusions: 18F-FDG-PET/CT detected lesions of clinical importance in one of seven IE patients and may be a substantial imaging technique for tracing peripheral infectious embolism due to IE. Thus, 18F-FDG-PET/CT may help to guide adequate therapy and thereby improve the prognosis of patients with IE.
机译：目的：本研究的目的是评估18F-FDG-PET / CT在感染性心内膜炎（IE）患者的额外心脏检查中的临床重要性。背景：IE是一种严重的疾病，死亡率很高。除瓣膜受累程度外，预后还主要取决于全身感染性栓塞的存在。方法：除标准的检查包括患者病史，体格检查，常规影像学检查和每周跨学科检查外，还对18例IE的72例患者（男性，平均年龄63±17岁）进行了18F-FDG-PET / CT评估会议。当通过后续检查确认通过18F-FDG-PET / CT检测到的先前未知病变时，它们被认为是真正的阳性新发现，并对其临床重要性进行了进一步评估。需要调查的人数计算为需要进行18F-FDG-PET / CT才能发现至少一项临床重要的真正阳性新发现的患者人数，而在18F-FDG-PET / CT之前没有通过标准检查确定。结果：18F-FDG-PET / CT检测出114处病变，其中64处为真阳性，其中25处是新发现，在17例患者中被发现。在11例患者中，病变被认为具有临床重要性;骨髓炎（n = 7），纤毛脓肿（n = 1），胃肠道病变（n = 2）和人工血管移植（n = 1）。需要调查的人数为7（72名患者中的11名）。结论：18F-FDG-PET / CT在7例IE患者中检测出具有临床意义的病变，可能是追踪IE引起的周围感染性栓塞的重要成像技术。因此，18F-FDG-PET / CT可能有助于指导适当的治疗，从而改善IE患者的预后。

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