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首页> 外文期刊>European archives of psychiatry and clinical neuroscience >Pharmacological long-term treatment strategies in first episode schizophreniaStudy design and preliminary results of an ongoing RCT within the German Research Network on Schizophrenia.
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Pharmacological long-term treatment strategies in first episode schizophreniaStudy design and preliminary results of an ongoing RCT within the German Research Network on Schizophrenia.

机译：首发精神分裂症的药理学长期治疗策略研究设计和德国精神分裂症研究网络中正在进行的RCT的初步结果。

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In first-episode schizophrenia the advantage of new atypical neuroleptics compared to low-dose haloperidol as well as the indicated duration of neuroleptic maintenance treatment has still to be based on empirical evidence.Accordingly, a multi-center study on the optimization of acute and long-term treatment in first-episode schizophrenia is currently being carried out as part of the German Research Network on Schizophrenia. This paper reports on the design, methods and preliminary results of the two-year randomized double-blind study comparing risperidone and low-dose haloperidol within the framework of psychological interventions. In the second treatment year, relapse rates under continued neuroleptic treatment are compared with those under stepwise drug withdrawal substituting instead prodrome-based early intervention (intermittent treatment).As to the results, by November 2003 142 first episode patients (ICD-10 F20) have been included in the long-term study. One-year relapse rates were very low (3.8%). On average, symptoms as well as drug side-effects decreased steadily under maintenance treatment. Although compliance on average was high, about 60% of the patients dropped out during the first study year. More pronounced psychopathology, (neurological) side-effects, lower compliance at study entry and absence of psychological treatment seemed to enhance the risk for drop-out.In conclusion, treatment in first episode schizophrenia is effective under both (further on blinded) neuroleptics; however these patients are at high risk for treatment drop-out. This emphasizes the need for a special support program.
机译：在首发型精神分裂症中，新的非典型抗精神病药相对于小剂量氟哌啶醇的优势以及所指示的精神抑制药维持治疗的时间仍需基于经验证据。因此，一项关于急性和长期优化的多中心研究目前，作为德国精神分裂症研究网络的一部分，正在进行首发精神分裂症的长期治疗。本文报告了为期两年的随机双盲研究的设计，方法和初步结果，该研究在心理干预的框架内比较了利培酮和小剂量氟哌啶醇。在第二个治疗年中，将持续的抗精神病药治疗与采用逐步停药替代基于前列腺癌的早期干预（间歇治疗）的复发率进行比较。结果，截至2003年11月，共有142例首发患者（ICD-10 F20）已纳入长期研究。一年复发率非常低（3.8％）。平均而言，在维持治疗的情况下，症状和药物副作用均稳定下降。尽管平均依从性很高，但在第一个研究年度中约有60％的患者退学。更明显的精神病理学，（神经学）副作用，研究开始时依从性降低以及缺乏心理治疗似乎增加了辍学的风险。总而言之，首发精神分裂症的治疗在两种（进一步盲法）抗精神病药均有效。但是这些患者极有可能退出治疗。这强调了需要特殊的支持计划。

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