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首页> 外文期刊>European journal of medical research. >The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases.
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The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases.

机译：与薄荷油相比，L-薄荷醇在人体单核细胞中具有抗炎活性：在炎症性疾病中具有治疗用途的新观点。

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The anti-inflammatory efficacy of monoterpenes is still unknown. In order to evaluate the potential role of L-menthol and mint oil as an anti-inflammatory drug, preclinical in vitro-investigations were performed using LPS-stimulated monocytes from healthy volunteers. Arachidonic acid metabolism was assessed by measuring LTB subset4 and PGE subset2 as indicators for both the lipoxygenase and the cyclooxygenase pathways respectively. In addition, the anti-inflammatory effects of the two terpenes on IL-1beta production were analysed. - L-menthol significantly suppressed the production of each of the three inflammation mediators by monocytes in vitro. LTB subset4 decreased by -64.4 +/- 10%, PGE subset2 by -56.6 +/- 8%, and IL-1beta by -64.2 +/- 7% respectively at L-menthol concentrations within the presumed therapeutic range of about 10 superset-7 g/ml. In contrast, mint oil had a bimodal effect on PGE subset2 production: lower concentrations of 10 superset-10 to 10 superset-8 g/ml increased PGE subset2 up to 6-fold compared to baseline but concentrations of 10 superset-7 g/ml suppressed PGE subset2 production by approximately 50%. Mint oil had similar effects on LTB subset4 and IL-1beta as its main constituent, L-menthol, although the degree of suppression was by comparison smaller at lower concentrations. Paraffin oil, which served as a solvent, did not affect arachidonic acid metabolism and IL-1beta production. - These results obtained with human monocytes suggest preferable anti-inflammatory effects of L-menthol compared to mint oil at therapeutically relevant concentrations supplied in enteric coated capsules. Therefore, clinical trials investigating the potential therapeutic efficacy of L-menthol for treatment of chronic inflammatory disorders such as bronchial asthma, colitis and allergic rhinitis seem worthwhile.
机译：单萜的抗炎功效仍然未知。为了评估L-薄荷醇和薄荷油作为抗炎药的潜在作用，使用来自健康志愿者的LPS刺激的单核细胞进行了临床前的体外研究。花生四烯酸的代谢是通过测量LTB子集4和PGE子集2分别作为脂氧合酶和环氧合酶途径的指标来评估的。另外，分析了两个萜烯对IL-1β产生的抗炎作用。 -L-薄荷醇显着抑制了单核细胞在体外产生的三种炎症介质。在大约10个超集的假定治疗范围内的L-薄荷醇浓度下，LTB亚群4下降-64.4 +/- 10％，PGE亚群2下降-56.6 +/- 8％，IL-1β下降-64.2 +/- 7％。 -7克/毫升。相比之下，薄荷油对PGE子集2的产生具有双峰效应：与基线相比，较低的10个superset-10到10个superset-8 g / ml的浓度可将PGE subset2增加到6倍，但浓度为10个superset-7 g / ml抑制PGE子集2产生约50％。薄荷油作为主要成分L-薄荷醇对LTB亚群4和IL-1beta具有相似的作用，尽管相比之下，在较低浓度下抑制作用的程度较小。用作溶剂的石蜡油不影响花生四烯酸的代谢和IL-1β的产生。 -与人单核细胞获得的这些结果表明，与肠溶衣胶囊中提供的治疗相关浓度的薄荷油相比，L-薄荷醇具有更好的抗炎作用。因此，研究L-薄荷醇治疗慢性炎性疾病如支气管哮喘，结肠炎和变应性鼻炎的潜在治疗功效的临床试验似乎是值得的。

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